Please use this identifier to cite or link to this item: https://doi.org/10.1117/1.JBO.22.4.045005
Title: Spread spectrum time-resolved diffuse optical measurement system for enhanced sensitivity in detecting human brain activity
Authors: Mehta, K 
Hasnain, A 
Zhou, X
Luo, J
Penney, T.B 
Chen, N 
Keywords: Neurons
Neurophysiology
Optical data processing
Spectroscopy
Diffuse optical imaging
Diffuse optical measurement
Diffuse optical spectroscopy
Enhanced sensitivity
Functional imaging
Non-invasive detection
Phantom experiment
Spread spectra
Brain
brain cortex
brain function
fluorescence imaging
human
photon
adult
brain
diagnostic imaging
economics
equipment design
imaging phantom
male
optical instrumentation
optical tomography
problem solving
procedures
reproducibility
spectroscopy
Adult
Brain
Diagnostic Imaging
Equipment Design
Humans
Male
Optical Devices
Phantoms, Imaging
Photons
Problem Solving
Reproducibility of Results
Spectrum Analysis
Tomography, Optical
Issue Date: 2017
Publisher: SPIE
Citation: Mehta, K, Hasnain, A, Zhou, X, Luo, J, Penney, T.B, Chen, N (2017). Spread spectrum time-resolved diffuse optical measurement system for enhanced sensitivity in detecting human brain activity. Journal of Biomedical Optics 22 (4) : 45005. ScholarBank@NUS Repository. https://doi.org/10.1117/1.JBO.22.4.045005
Abstract: Diffuse optical spectroscopy (DOS) and imaging methods have been widely applied to noninvasive detection of brain activity. We have designed and implemented a low cost, portable, real-time one-channel time-resolved DOS system for neuroscience studies. Phantom experiments were carried out to test the performance of the system. We further conducted preliminary human experiments and demonstrated that enhanced sensitivity in detecting neural activity in the cortex could be achieved by the use of late arriving photons. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Source Title: Journal of Biomedical Optics
URI: https://scholarbank.nus.edu.sg/handle/10635/175228
ISSN: 1083-3668
DOI: 10.1117/1.JBO.22.4.045005
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