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https://doi.org/10.1128/AAC.01298-17
| Title: | Vancomycin and clarithromycin show synergy against Mycobacterium abscessus in vitro | Authors: | Mukherjee, D Wu, M.-L Teo, J.W.P Dick, T |
Keywords: | clarithromycin vancomycin clarithromycin tuberculostatic agent vancomycin antibacterial activity Article bacterial growth bacterium isolate controlled study drug effect drug potentiation fractional inhibitory concentration index gene mutation in vitro study minimum inhibitory concentration Mycobacterium abscessus Mycobacterium massiliense nonhuman nucleotide sequence priority journal type strain atypical mycobacteriosis combination drug therapy drug effect drug potentiation human lung disease microbial sensitivity test microbiology Mycobacterium abscessus treatment outcome Antibiotics, Antitubercular Clarithromycin Drug Synergism Drug Therapy, Combination Humans Lung Diseases Microbial Sensitivity Tests Mycobacterium abscessus Mycobacterium Infections, Nontuberculous Treatment Outcome Vancomycin |
Issue Date: | 2017 | Publisher: | American Society for Microbiology | Citation: | Mukherjee, D, Wu, M.-L, Teo, J.W.P, Dick, T (2017). Vancomycin and clarithromycin show synergy against Mycobacterium abscessus in vitro. Antimicrobial Agents and Chemotherapy 61 (12) : e01298. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.01298-17 | Abstract: | Lung disease caused by Mycobacterium abscessus is increasing, and current clarithromycin-based treatment regimens are only moderately effective. Here, we determined the effect of clarithromycin-vancomycin combination against M. abscessus complex isolates in vitro. Synergy was found with a fractional inhibitory concentration index (FICI) score of ?0.5 and a 4- to 10-fold decrease in MIC. © 2017 Mukherjee et al. | Source Title: | Antimicrobial Agents and Chemotherapy | URI: | https://scholarbank.nus.edu.sg/handle/10635/175145 | ISSN: | 0066-4804 | DOI: | 10.1128/AAC.01298-17 |
| Appears in Collections: | Staff Publications Elements |
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