Please use this identifier to cite or link to this item: https://doi.org/10.1128/AAC.01298-17
Title: Vancomycin and clarithromycin show synergy against Mycobacterium abscessus in vitro
Authors: Mukherjee, D 
Wu, M.-L 
Teo, J.W.P
Dick, T 
Keywords: clarithromycin
vancomycin
clarithromycin
tuberculostatic agent
vancomycin
antibacterial activity
Article
bacterial growth
bacterium isolate
controlled study
drug effect
drug potentiation
fractional inhibitory concentration index
gene mutation
in vitro study
minimum inhibitory concentration
Mycobacterium abscessus
Mycobacterium massiliense
nonhuman
nucleotide sequence
priority journal
type strain
atypical mycobacteriosis
combination drug therapy
drug effect
drug potentiation
human
lung disease
microbial sensitivity test
microbiology
Mycobacterium abscessus
treatment outcome
Antibiotics, Antitubercular
Clarithromycin
Drug Synergism
Drug Therapy, Combination
Humans
Lung Diseases
Microbial Sensitivity Tests
Mycobacterium abscessus
Mycobacterium Infections, Nontuberculous
Treatment Outcome
Vancomycin
Issue Date: 2017
Publisher: American Society for Microbiology
Citation: Mukherjee, D, Wu, M.-L, Teo, J.W.P, Dick, T (2017). Vancomycin and clarithromycin show synergy against Mycobacterium abscessus in vitro. Antimicrobial Agents and Chemotherapy 61 (12) : e01298. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.01298-17
Abstract: Lung disease caused by Mycobacterium abscessus is increasing, and current clarithromycin-based treatment regimens are only moderately effective. Here, we determined the effect of clarithromycin-vancomycin combination against M. abscessus complex isolates in vitro. Synergy was found with a fractional inhibitory concentration index (FICI) score of ?0.5 and a 4- to 10-fold decrease in MIC. © 2017 Mukherjee et al.
Source Title: Antimicrobial Agents and Chemotherapy
URI: https://scholarbank.nus.edu.sg/handle/10635/175145
ISSN: 0066-4804
DOI: 10.1128/AAC.01298-17
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