Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-18039-w
Title: Automated Detection of Iris Furrows and their Influence on Dynamic Iris Volume Change
Authors: Chua, J 
Thakku, S.G
Pham, T.H 
Lee, R
Tun, T.A
Nongpiur, M.E 
Tan, M.C.L
Wong, T.Y 
Quah, J.H.M 
Aung, T 
Girard, M.J.A 
Cheng, C.-Y 
Keywords: anatomy and histology
female
human
intraocular pressure
iris
male
middle aged
optical coherence tomography
physiology
procedures
prospective study
pupil
Female
Humans
Intraocular Pressure
Iris
Male
Middle Aged
Prospective Studies
Pupil
Tomography, Optical Coherence
Issue Date: 2017
Citation: Chua, J, Thakku, S.G, Pham, T.H, Lee, R, Tun, T.A, Nongpiur, M.E, Tan, M.C.L, Wong, T.Y, Quah, J.H.M, Aung, T, Girard, M.J.A, Cheng, C.-Y (2017). Automated Detection of Iris Furrows and their Influence on Dynamic Iris Volume Change. Scientific Reports 7 (1) : 17894. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-18039-w
Abstract: We introduced a new method for detecting iris surface furrows and identify its associations with dynamic changes in iris volume in healthy eyes. Swept-source optical coherence tomography was performed on 65 subjects with open angle under light and dark conditions. Iris boundaries were identified and a reconstruction of the anterior iris surface was obtained. Furrows were detected by identifying locally deep (minima) points on the iris surface and reported as furrow length in millimetres. Iris volume was quantified. Associations between furrow length and dynamic changes in iris volume were assessed using linear regression model. With pupil dilation, furrow length increased (15.84 mm) whereas iris volume decreased (-1.19 ± 0.66 mm3). Longer furrow length was associated with larger static iris volume, as well as smaller loss of iris volume with pupil dilation (? = -0.10, representing 0.1 mm3 less loss in iris volume per 10 mm increase in iris furrow length; P = 0.002, adjusted for age, gender and changes in pupil size). Our iris furrow length measurements are robust and intuitive. Eyes with longer furrows have larger iris volume and lose less volume during physiological pupil dilation. These findings highlight the potential for iris surface features as indicators of iris morphological behavior. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175084
ISSN: 20452322
DOI: 10.1038/s41598-017-18039-w
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