Please use this identifier to cite or link to this item: https://doi.org/10.1161/JAHA.118.008911
Title: Association of "elevated blood pressure" and "stage 1 hypertension" with cardiovascular mortality among an Asian population
Authors: Talaei, M
Hosseini, N 
Koh, A.S 
Yuan, J.-M
Koh, W.-P 
Keywords: adult
aged
Article
cardiovascular mortality
Chinese
cohort analysis
controlled study
diastolic blood pressure
elevated blood pressure
female
follow up
human
hypertension
lifestyle
male
mortality risk
observational study
priority journal
Singapore
staging
systolic blood pressure
blood pressure
blood pressure measurement
cardiovascular disease
cause of death
clinical trial
diastole
epidemiology
exercise
hypertension
middle aged
mortality
multicenter study
pathophysiology
physiology
prognosis
retrospective study
risk factor
survival rate
systole
Aged
Blood Pressure
Blood Pressure Determination
Cardiovascular Diseases
Cause of Death
Diastole
Exercise
Female
Humans
Hypertension
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Singapore
Survival Rate
Systole
Issue Date: 2018
Citation: Talaei, M, Hosseini, N, Koh, A.S, Yuan, J.-M, Koh, W.-P (2018). Association of "elevated blood pressure" and "stage 1 hypertension" with cardiovascular mortality among an Asian population. Journal of the American Heart Association 7 (8) : e008911. ScholarBank@NUS Repository. https://doi.org/10.1161/JAHA.118.008911
Abstract: Background--The new American College of Cardiology/American Heart Association high blood pressure (BP) guidelines in the United States have lowered definition of hypertension by defining normal as systolic/diastolic BP < 120/80 mm Hg; elevated BP as systolic between 120 and 129 mm Hg and diastolic < 80 mm Hg; and stage 1 hypertension as systolic between 130 and 139 mm Hg or diastolic between 80 and 89 mm Hg. Methods and Results--We investigated the association between the new hypertension definition and cardiovascular disease mortality among Chinese in Singapore. We used data from 30 636 participants of a population-based cohort, the SCHS (Singapore Chinese Health Study), who had BPs measured using a standard protocol at ages 46 to 85 years between 1994 and 2005. Information on lifestyle factors was collected at recruitment (1993-1998) and follow-up 1 interviews (1999 and 2004). Mortality was identified via nationwide registry linkage up to December 31, 2016. Neither elevated BP (hazard ratio, 0.89; 95% confidence interval, 0.74-1.07) nor stage 1 hypertension (hazard ratio, 0.94; 95% confidence interval, 0.81-1.11) was associated with increased risk of cardiovascular mortality compared with normal BP in the whole cohort. Stage 1 hypertension was associated with increased cardiovascular risk only in those < 65 years of age and without a history of cardiovascular disease (hazard ratio, 1.40; 95% confidence interval, 1.01-1.94), but not in those ?65 years of age or with a history of cardiovascular disease. Conclusions--Our data suggest that the newly defined stage 1 hypertension may not be associated with increased cardiovascular mortality across all ages among Chinese in Singapore, but that the at-risk subpopulation is limited to those < 65 years of age and without a prior cardiovascular disease. © 2018 The Authors.
Source Title: Journal of the American Heart Association
URI: https://scholarbank.nus.edu.sg/handle/10635/175063
ISSN: 20479980
DOI: 10.1161/JAHA.118.008911
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