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Title: Bat-mouse bone marrow chimera: A novel animal model for dissecting the uniqueness of the bat immune system
Authors: Yong, K.S.M
Ng, J.H.J 
Her, Z
Hey, Y.Y 
Tan, S.Y
Tan, W.W.S
Irac, S.E 
Liu, M
Chan, X.Y
Gunawan, M
Foo, R.J.H 
Low, D.H.W 
Mendenhall, I.H 
Chionh, Y.T 
Dutertre, C.-A 
Chen, Q 
Wang, L.-F 
Keywords: animal
bone marrow transplantation
graft rejection
graft survival
nonobese diabetic mouse
SCID mouse
severe combined immunodeficiency
Bone Marrow Transplantation
Graft Rejection
Graft Survival
Mice, Inbred NOD
Mice, SCID
Severe Combined Immunodeficiency
Transplantation Chimera
Issue Date: 2018
Citation: Yong, K.S.M, Ng, J.H.J, Her, Z, Hey, Y.Y, Tan, S.Y, Tan, W.W.S, Irac, S.E, Liu, M, Chan, X.Y, Gunawan, M, Foo, R.J.H, Low, D.H.W, Mendenhall, I.H, Chionh, Y.T, Dutertre, C.-A, Chen, Q, Wang, L.-F (2018). Bat-mouse bone marrow chimera: A novel animal model for dissecting the uniqueness of the bat immune system. Scientific Reports 8 (1) : 4726. ScholarBank@NUS Repository.
Abstract: Bats are an important animal model with long lifespans, low incidences of tumorigenesis and an ability to asymptomatically harbour pathogens. Currently, in vivo studies of bats are hampered due to their low reproduction rates. To overcome this, we transplanted bat cells from bone marrow (BM) and spleen into an immunodeficient mouse strain NOD-scid IL-2R-/- (NSG), and have successfully established stable, long-Term reconstitution of bat immune cells in mice (bat-mice). Immune functionality of our bat-mouse model was demonstrated through generation of antigen-specific antibody response by bat cells following immunization. Post-engraftment of total bat BM cells and splenocytes, bat immune cells survived, expanded and repopulated the mouse without any observable clinical abnormalities. Utilizing bat's remarkable immunological functions, this novel model has a potential to be transformed into a powerful platform for basic and translational research. © 2018 The Author(s).
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/s41598-018-22899-1
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