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https://doi.org/10.18632/oncotarget.7157
| Title: | NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition | Authors: | Madan, B Ke, Z Lei, Z.D Oliver, F.A Oshima, M Lee, M.A Rozen, S Virshup, D.M |
Keywords: | AXIN2 protein biological marker esterase Notum protein unclassified drug acyltransferase axin AXIN2 protein, human esterase ETC-159 fused heterocyclic rings membrane protein Notum protein, human PORCN protein, human tumor marker animal experiment animal model Article autocrine effect blood analysis controlled study in vitro study in vivo study intracellular signaling mouse nonhuman prediction protein determination protein expression protein secretion Wnt signaling pathway animal antagonists and inhibitors Bagg albino mouse biosynthesis C57BL mouse down regulation drug effects fibrosarcoma genetic transfection human metabolism nude mouse pancreas tumor tumor cell line Wnt signaling xenograft Acyltransferases Animals Axin Protein Biomarkers, Tumor Cell Line, Tumor Down-Regulation Esterases Fibrosarcoma Heterocyclic Compounds, 4 or More Rings Heterografts Humans Membrane Proteins Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Pancreatic Neoplasms Transfection Wnt Signaling Pathway |
Issue Date: | 2016 | Publisher: | Impact Journals LLC | Citation: | Madan, B, Ke, Z, Lei, Z.D, Oliver, F.A, Oshima, M, Lee, M.A, Rozen, S, Virshup, D.M (2016). NOTUM is a potential pharmacodynamic biomarker of wnt pathway inhibition. Oncotarget 7 (11) : 12386-12392. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.7157 | Abstract: | Activation of Wnt signaling due to Wnt overexpression or mutations of Wnt pathway components is associated with various cancers. Blocking Wnt secretion by inhibiting PORCN enzymatic activity has shown efficacy in a subset of cancers with elevated Wnt signaling. Predicting response to upstream Wnt inhibitors and monitoring response to therapeutics is challenging due to the paucity of well-defined biomarkers. In this study we identify Notum as a potential biomarker for Wnt driven cancers and show that coordinate regulation of NOTUM and AXIN2 expression may be a useful predictor of response to PORCN inhibitors. Most importantly, as NOTUM is a secreted protein and its levels in blood correlate with tumor growth, it has potential as a pharmacodynamic biomarker for PORCN and other Wnt pathway inhibitors. | Source Title: | Oncotarget | URI: | https://scholarbank.nus.edu.sg/handle/10635/174984 | ISSN: | 19492553 | DOI: | 10.18632/oncotarget.7157 |
| Appears in Collections: | Elements Staff Publications |
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