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Title: Enantioselective desymmetrization of cyclohexadienones via an intramolecular Rauhut-Currier reaction of allenoates
Authors: Yao, W 
Dou, X 
Wen, S 
Wu, J 
Vittal, J.J 
Lu, Y 
Keywords: carbon
chemical bonding
chemical reaction
organic compound
reaction kinetics
chemical reaction kinetics
substitution reaction
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Yao, W, Dou, X, Wen, S, Wu, J, Vittal, J.J, Lu, Y (2016). Enantioselective desymmetrization of cyclohexadienones via an intramolecular Rauhut-Currier reaction of allenoates. Nature Communications 7 : 13024. ScholarBank@NUS Repository.
Abstract: The Rauhut-Currier (RC) reaction represents an efficient method for the construction of carbon-carbon bond in organic synthesis. However, the RC reactions involving allenoate substrates are very rare, and in particular, asymmetric intramolecular RC reaction of allenoates is yet to be discovered. Here, we show that the intramolecular RC reaction proceeds smoothly in the presence of 1 mol% ?-ICD, and bicyclic lactones are obtained in high yields and with excellent enantiomeric excesses. With the employment of 3-substituted allenoates as racemic precursors, a novel dynamic kinetic resolution of allenes via RC reaction is observed, which allows for facile synthesis of highly enantiomerically enriched allenes. © The Author(s) 2016.
Source Title: Nature Communications
ISSN: 20411723
DOI: 10.1038/ncomms13024
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