Please use this identifier to cite or link to this item: https://doi.org/10.3389/fbioe.2014.00078
Title: Production of fatty acid-derived valuable chemicals in synthetic microbes
Authors: Yu A.-Q. 
Pratomo Juwono N.K. 
Leong S.S.J. 
Chang M.W. 
Keywords: Alcohols
Bacteria
Biochemistry
Biology
Chemicals
Computer control systems
Escherichia coli
Gene expression
Gene expression regulation
Indicators (chemical)
Metabolic engineering
Metabolism
Microorganisms
Plastics applications
Yeast
Biological sources
Economically viable
Fatty acid biosynthesis
Fatty acid derivatives
Hydroxy fatty acids
Secondary structures
Synthetic biology
Valuable chemicals
Fatty acids
Issue Date: 2014
Citation: Yu A.-Q., Pratomo Juwono N.K., Leong S.S.J., Chang M.W. (2014). Production of fatty acid-derived valuable chemicals in synthetic microbes. Frontiers in Bioengineering and Biotechnology 2 (DEC) : 78. ScholarBank@NUS Repository. https://doi.org/10.3389/fbioe.2014.00078
Abstract: Fatty acid derivatives, such as hydroxy fatty acids, fatty alcohols, fatty acid methyl/ethyl esters, and fatty alka(e)nes, have a wide range of industrial applications including plastics, lubricants, and fuels. Currently, these chemicals are obtained mainly through chemical synthesis, which is complex and costly, and their availability from natural biological sources is extremely limited. Metabolic engineering of microorganisms has provided a platform for effective production of these valuable biochemicals. Notably, synthetic biology-based metabolic engineering strategies have been extensively applied to refactor microorganisms for improved biochemical production. Here, we reviewed: (i) the current status of metabolic engineering of microbes that produce fatty acid-derived valuable chemicals, and (ii) the recent progress of synthetic biology approaches that assist metabolic engineering, such as mRNA secondary structure engineering, sensor-regulator system, regulatable expression system, ultrasensitive input/output control system, and computer science-based design of complex gene circuits. Furthermore, key challenges and strategies were discussed. Finally, we concluded that synthetic biology provides useful metabolic engineering strategies for economically viable production of fatty acid-derived valuable chemicals in engineered microbes. © 2014 Yu, Pratomo Juwono, Leong and Chang.
Source Title: Frontiers in Bioengineering and Biotechnology
URI: https://scholarbank.nus.edu.sg/handle/10635/174651
ISSN: 2296-4185
DOI: 10.3389/fbioe.2014.00078
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