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Title: Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for Long-Term In Situ Monitoring of Liver Tumor Growth
Authors: Liu, J 
Li, K
Liu, B 
Issue Date: 2015
Citation: Liu, J, Li, K, Liu, B (2015). Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for Long-Term In Situ Monitoring of Liver Tumor Growth. Advanced Science 2 (5) : 1500008. ScholarBank@NUS Repository.
Abstract: The design and synthesis is reported for a fluorescent conjugated polymer (CP), poly{[4,4,9,9-tetrakis(4-(octyloxy)phenyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b′]dithiophene)]-alt-co-[4,7-di(thiophen-2-yl)-2,1,3-benzothiadiazole]} (PIDT-DBT), with absorption and emission profiles fallen within far-red/near infrared (FR/NIR) region and further demonstrate its application in long-term in vitro cell tracing and in vivo imaging of liver tumor growth. PIDT-DBT-Tat nanoparticles (NPs) have an absorption maximum at ≈600 nm with an emission maximum at ≈720 nm in water. In vitro cell tracing studies reveal that PIDT-DBT-Tat NPs can trace HepG2 liver cancer cells over 8 d. In vivo imaging results indicate that PIDT-DBT-Tat NPs can monitor liver tumor growth for more than 27 d in a real-time manner. Both in vitro and in vivo studies demonstrate that PIDT-DBT-Tat NPs are superior to commercial Qtracker 705 as fluorescent probes. This study demonstrates for the first time the feasibility for long-term in vivo imaging of tumor growth by utilizing CP-based fluorescent probes, which will encourage the development of NIR fluorescent CPs for in vivo bioimaging. © 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Source Title: Advanced Science
ISSN: 2198-3844
DOI: 10.1002/advs.201500008
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