Please use this identifier to cite or link to this item: https://doi.org/10.1002/advs.201500008
DC FieldValue
dc.titleFar-Red/Near-Infrared Conjugated Polymer Nanoparticles for Long-Term In Situ Monitoring of Liver Tumor Growth
dc.contributor.authorLiu, J
dc.contributor.authorLi, K
dc.contributor.authorLiu, B
dc.date.accessioned2020-09-08T03:48:57Z
dc.date.available2020-09-08T03:48:57Z
dc.date.issued2015
dc.identifier.citationLiu, J, Li, K, Liu, B (2015). Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for Long-Term In Situ Monitoring of Liver Tumor Growth. Advanced Science 2 (5) : 1500008. ScholarBank@NUS Repository. https://doi.org/10.1002/advs.201500008
dc.identifier.issn2198-3844
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174640
dc.description.abstractThe design and synthesis is reported for a fluorescent conjugated polymer (CP), poly{[4,4,9,9-tetrakis(4-(octyloxy)phenyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b′]dithiophene)]-alt-co-[4,7-di(thiophen-2-yl)-2,1,3-benzothiadiazole]} (PIDT-DBT), with absorption and emission profiles fallen within far-red/near infrared (FR/NIR) region and further demonstrate its application in long-term in vitro cell tracing and in vivo imaging of liver tumor growth. PIDT-DBT-Tat nanoparticles (NPs) have an absorption maximum at ≈600 nm with an emission maximum at ≈720 nm in water. In vitro cell tracing studies reveal that PIDT-DBT-Tat NPs can trace HepG2 liver cancer cells over 8 d. In vivo imaging results indicate that PIDT-DBT-Tat NPs can monitor liver tumor growth for more than 27 d in a real-time manner. Both in vitro and in vivo studies demonstrate that PIDT-DBT-Tat NPs are superior to commercial Qtracker 705 as fluorescent probes. This study demonstrates for the first time the feasibility for long-term in vivo imaging of tumor growth by utilizing CP-based fluorescent probes, which will encourage the development of NIR fluorescent CPs for in vivo bioimaging. © 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.sourceUnpaywall 20200831
dc.typeArticle
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.description.doi10.1002/advs.201500008
dc.description.sourcetitleAdvanced Science
dc.description.volume2
dc.description.issue5
dc.description.page1500008
dc.published.statePublished
Appears in Collections:Elements
Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1002_advs_201500008.pdf836.49 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

37
checked on Sep 19, 2021

Page view(s)

104
checked on Sep 10, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.