Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-18709-9
Title: Plasma adiponectin levels and type 2 diabetes risk: A nested case-control study in a Chinese population and an updated meta-analysis
Authors: Wang, Y 
Meng, R.-W
Kunutsor, S.K
Chowdhury, R
Yuan, J.-M
Koh, W.-P 
Pan, A
Keywords: adiponectin
aged
blood
body mass
case control study
China
female
human
male
meta analysis
middle aged
non insulin dependent diabetes mellitus
odds ratio
prospective study
risk factor
Adiponectin
Aged
Body Mass Index
Case-Control Studies
China
Diabetes Mellitus, Type 2
Female
Humans
Male
Middle Aged
Odds Ratio
Prospective Studies
Risk Factors
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Wang, Y, Meng, R.-W, Kunutsor, S.K, Chowdhury, R, Yuan, J.-M, Koh, W.-P, Pan, A (2018). Plasma adiponectin levels and type 2 diabetes risk: A nested case-control study in a Chinese population and an updated meta-analysis. Scientific Reports 8 (1) : 406. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-18709-9
Abstract: Results from previous prospective studies assessing the relation between adiponectin and type 2 diabetes (T2D) were not entirely consistent, and evidence in Chinese population is scarce. Moreover, the last meta-analysis did not examine the impact of metabolic variables on the adiponectin-T2D association. Therefore, we prospectively evaluated the adiponectin-T2D association among 571 T2D cases and 571 age-sex-matched controls nested within the Singapore Chinese Health Study (SCHS). Furthermore, we conducted an updated meta-analysis by searching prospective studies on Pubmed till September 2016. In the SCHS, the odds ratio of T2D, comparing the highest versus lowest tertile of adiponectin levels, was 0.30 (95% confidence interval: 0.17, 0.55) in the fully-adjusted model. The relation was stronger among heavier participants (body mass index ?23 kg/m2) compared to their leaner counterparts (P for interaction = 0.041). In a meta-analysis of 34 prospective studies, the pooled relative risk was 0.53 (95% confidence interval: 0.47, 0.61) comparing the extreme tertiles of adiponectin with moderate heterogeneity (I 2 = 48.7%, P = 0.001). The adiponectin-T2D association remained unchanged after adjusting for inflammation and dyslipidemia markers, but substantially attenuated with adjustment for insulin sensitivity and/or glycaemia markers. Overall evidence indicates that higher adiponectin levels are associated with decreased T2D risk in Chinese and other populations. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174349
ISSN: 2045-2322
DOI: 10.1038/s41598-017-18709-9
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