Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41598-017-18709-9
DC Field | Value | |
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dc.title | Plasma adiponectin levels and type 2 diabetes risk: A nested case-control study in a Chinese population and an updated meta-analysis | |
dc.contributor.author | Wang, Y | |
dc.contributor.author | Meng, R.-W | |
dc.contributor.author | Kunutsor, S.K | |
dc.contributor.author | Chowdhury, R | |
dc.contributor.author | Yuan, J.-M | |
dc.contributor.author | Koh, W.-P | |
dc.contributor.author | Pan, A | |
dc.date.accessioned | 2020-09-04T02:21:35Z | |
dc.date.available | 2020-09-04T02:21:35Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Wang, Y, Meng, R.-W, Kunutsor, S.K, Chowdhury, R, Yuan, J.-M, Koh, W.-P, Pan, A (2018). Plasma adiponectin levels and type 2 diabetes risk: A nested case-control study in a Chinese population and an updated meta-analysis. Scientific Reports 8 (1) : 406. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-18709-9 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/174349 | |
dc.description.abstract | Results from previous prospective studies assessing the relation between adiponectin and type 2 diabetes (T2D) were not entirely consistent, and evidence in Chinese population is scarce. Moreover, the last meta-analysis did not examine the impact of metabolic variables on the adiponectin-T2D association. Therefore, we prospectively evaluated the adiponectin-T2D association among 571 T2D cases and 571 age-sex-matched controls nested within the Singapore Chinese Health Study (SCHS). Furthermore, we conducted an updated meta-analysis by searching prospective studies on Pubmed till September 2016. In the SCHS, the odds ratio of T2D, comparing the highest versus lowest tertile of adiponectin levels, was 0.30 (95% confidence interval: 0.17, 0.55) in the fully-adjusted model. The relation was stronger among heavier participants (body mass index ?23 kg/m2) compared to their leaner counterparts (P for interaction = 0.041). In a meta-analysis of 34 prospective studies, the pooled relative risk was 0.53 (95% confidence interval: 0.47, 0.61) comparing the extreme tertiles of adiponectin with moderate heterogeneity (I 2 = 48.7%, P = 0.001). The adiponectin-T2D association remained unchanged after adjusting for inflammation and dyslipidemia markers, but substantially attenuated with adjustment for insulin sensitivity and/or glycaemia markers. Overall evidence indicates that higher adiponectin levels are associated with decreased T2D risk in Chinese and other populations. © 2017 The Author(s). | |
dc.publisher | Nature Publishing Group | |
dc.source | Unpaywall 20200831 | |
dc.subject | adiponectin | |
dc.subject | aged | |
dc.subject | blood | |
dc.subject | body mass | |
dc.subject | case control study | |
dc.subject | China | |
dc.subject | female | |
dc.subject | human | |
dc.subject | male | |
dc.subject | meta analysis | |
dc.subject | middle aged | |
dc.subject | non insulin dependent diabetes mellitus | |
dc.subject | odds ratio | |
dc.subject | prospective study | |
dc.subject | risk factor | |
dc.subject | Adiponectin | |
dc.subject | Aged | |
dc.subject | Body Mass Index | |
dc.subject | Case-Control Studies | |
dc.subject | China | |
dc.subject | Diabetes Mellitus, Type 2 | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Odds Ratio | |
dc.subject | Prospective Studies | |
dc.subject | Risk Factors | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1038/s41598-017-18709-9 | |
dc.description.sourcetitle | Scientific Reports | |
dc.description.volume | 8 | |
dc.description.issue | 1 | |
dc.description.page | 406 | |
Appears in Collections: | Elements Staff Publications |
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