Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-18709-9
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dc.titlePlasma adiponectin levels and type 2 diabetes risk: A nested case-control study in a Chinese population and an updated meta-analysis
dc.contributor.authorWang, Y
dc.contributor.authorMeng, R.-W
dc.contributor.authorKunutsor, S.K
dc.contributor.authorChowdhury, R
dc.contributor.authorYuan, J.-M
dc.contributor.authorKoh, W.-P
dc.contributor.authorPan, A
dc.date.accessioned2020-09-04T02:21:35Z
dc.date.available2020-09-04T02:21:35Z
dc.date.issued2018
dc.identifier.citationWang, Y, Meng, R.-W, Kunutsor, S.K, Chowdhury, R, Yuan, J.-M, Koh, W.-P, Pan, A (2018). Plasma adiponectin levels and type 2 diabetes risk: A nested case-control study in a Chinese population and an updated meta-analysis. Scientific Reports 8 (1) : 406. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-18709-9
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174349
dc.description.abstractResults from previous prospective studies assessing the relation between adiponectin and type 2 diabetes (T2D) were not entirely consistent, and evidence in Chinese population is scarce. Moreover, the last meta-analysis did not examine the impact of metabolic variables on the adiponectin-T2D association. Therefore, we prospectively evaluated the adiponectin-T2D association among 571 T2D cases and 571 age-sex-matched controls nested within the Singapore Chinese Health Study (SCHS). Furthermore, we conducted an updated meta-analysis by searching prospective studies on Pubmed till September 2016. In the SCHS, the odds ratio of T2D, comparing the highest versus lowest tertile of adiponectin levels, was 0.30 (95% confidence interval: 0.17, 0.55) in the fully-adjusted model. The relation was stronger among heavier participants (body mass index ?23 kg/m2) compared to their leaner counterparts (P for interaction = 0.041). In a meta-analysis of 34 prospective studies, the pooled relative risk was 0.53 (95% confidence interval: 0.47, 0.61) comparing the extreme tertiles of adiponectin with moderate heterogeneity (I 2 = 48.7%, P = 0.001). The adiponectin-T2D association remained unchanged after adjusting for inflammation and dyslipidemia markers, but substantially attenuated with adjustment for insulin sensitivity and/or glycaemia markers. Overall evidence indicates that higher adiponectin levels are associated with decreased T2D risk in Chinese and other populations. © 2017 The Author(s).
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subjectadiponectin
dc.subjectaged
dc.subjectblood
dc.subjectbody mass
dc.subjectcase control study
dc.subjectChina
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmeta analysis
dc.subjectmiddle aged
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectodds ratio
dc.subjectprospective study
dc.subjectrisk factor
dc.subjectAdiponectin
dc.subjectAged
dc.subjectBody Mass Index
dc.subjectCase-Control Studies
dc.subjectChina
dc.subjectDiabetes Mellitus, Type 2
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOdds Ratio
dc.subjectProspective Studies
dc.subjectRisk Factors
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41598-017-18709-9
dc.description.sourcetitleScientific Reports
dc.description.volume8
dc.description.issue1
dc.description.page406
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