Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-18354-2
Title: Imaging 4D morphology and dynamics of mitral annulus in humans using cardiac cine MR feature tracking
Authors: Leng, S
Zhang, S
Jiang, M
Zhao, X
Wu, R
Allen, J 
He, B
Tan, R.S 
Zhong, L 
Keywords: adult
aged
case control study
cine magnetic resonance imaging
diagnostic imaging
heart function test
human
image processing
middle aged
mitral valve
mitral valve regurgitation
observer variation
pathology
pathophysiology
procedures
reproducibility
severity of illness index
three dimensional imaging
Adult
Aged
Case-Control Studies
Heart Function Tests
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Magnetic Resonance Imaging, Cine
Middle Aged
Mitral Valve
Mitral Valve Insufficiency
Observer Variation
Reproducibility of Results
Severity of Illness Index
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Leng, S, Zhang, S, Jiang, M, Zhao, X, Wu, R, Allen, J, He, B, Tan, R.S, Zhong, L (2018). Imaging 4D morphology and dynamics of mitral annulus in humans using cardiac cine MR feature tracking. Scientific Reports 8 (1) : 81. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-18354-2
Abstract: Feature tracking in cine cardiac magnetic resonance (CMR) is a quantitative technique to assess heart structure and function. We investigated 4-dimensional (4D) dynamics and morphology of the mitral annulus (MA) using a novel tracking system based on radially rotational long-Axis cine CMR series. A total of 30 normal controls and patients with mitral regurgitation were enrolled. The spatiotemporal changes of the MA were characterized by an in-house developed program. Dynamic and morphological parameters extracted from all 18 radial slices were used as references and were compared with those from subsequently generated sub-datasets with different degrees of sparsity. An excellent agreement was found among all datasets including routine 2-, 3-and 4-chamber views for MA dynamics such as peak systolic velocity (Sm) and mitral annular plane systolic excursion (MAPSE). MA morphology for size and shape was addressed adequately by as few as 6 radial slices, but poorly by only three routine views. Patients with regurgitation showed significantly reduced mitral dynamics and mild annular deformation, which was consistent between three routine views and 18 reference slices. In conclusion, feature tracking cine CMR provided a comprehensive and distinctive profile for 4D MA dynamics and morphology, which may help in studying different cardiac diseases. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174313
ISSN: 2045-2322
DOI: 10.1038/s41598-017-18354-2
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