Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-27202-w
Title: Six-Year Incidence and Risk Factors of Age-Related Macular Degeneration in Singaporean
Authors: Foo, V.H.X
Yanagi, Y 
Nguyen, Q.D
Sabanayagam, C 
Lim, S.H
Neelam, K 
Wang, J.J 
Mitchell, P
Cheng, C.-Y 
Wong, T.Y 
Cheung, C.M.G 
Keywords: ARMS2 protein, human
protein
aged
alcoholism
cardiovascular disease
cohort analysis
female
gene locus
genetic predisposition
genetics
homozygote
human
incidence
India
macular degeneration
male
middle aged
prevalence
retrospective study
risk factor
Singapore
time factor
underweight
Aged
Alcoholism
Cardiovascular Diseases
Cohort Studies
Female
Genetic Loci
Genetic Predisposition to Disease
Homozygote
Humans
Incidence
India
Macular Degeneration
Male
Middle Aged
Prevalence
Proteins
Retrospective Studies
Risk Factors
Singapore
Thinness
Time Factors
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Foo, V.H.X, Yanagi, Y, Nguyen, Q.D, Sabanayagam, C, Lim, S.H, Neelam, K, Wang, J.J, Mitchell, P, Cheng, C.-Y, Wong, T.Y, Cheung, C.M.G (2018). Six-Year Incidence and Risk Factors of Age-Related Macular Degeneration in Singaporean. Scientific Reports 8 (1) : 8869. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-27202-w
Abstract: We aimed to determine the 6-year incidence and risk factors of age-related macular degeneration (AMD) in first and second generations of Singaporean Indians. Baseline examination was conducted in 2007-9 and 6-year propsective follow-up examination of this Indian population in 2013-5. All participants underwent interviews with questionnaires and comprehensive medical and eye examinations. Incidence was age-standardized to Singaporean 2010 census. Risk factors associated with AMD incidence were assessed and compared between first and second generations of immigrants. Among 2200 persons who participated in the follow-up examination (75.5% response rate), gradable fundus photographs were available in 2105. The 6-year age-standardized incidences of early and late AMD were 5.26% and 0.51% respectively. Incident early AMD was associated with cardiovascular disease history (HR 1.59, 95% CI 1.04-2.45), underweight body mass index (BMI) (HR 3.12, 95% CI 1.37-7.14) (BMI of <18.5 vs 18.51-25 kg/m2), heavy alcohol drinking (HR 3.14 95% CI 1.25-7.89) and ARMS2 rs3750847 homozygous genetic loci carrier (HR 2.52, 95% CI 1.59-3.99). We found a relatively low incidence of early AMD in this Singaporean Indian population compared to Caucasian populations. Both first and second-generation Indian immigrants have similar incidence and risk factor patterns for early AMD. © 2018 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174215
ISSN: 2045-2322
DOI: 10.1038/s41598-018-27202-w
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