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https://doi.org/10.1038/s41598-018-27202-w
Title: | Six-Year Incidence and Risk Factors of Age-Related Macular Degeneration in Singaporean | Authors: | Foo, V.H.X Yanagi, Y Nguyen, Q.D Sabanayagam, C Lim, S.H Neelam, K Wang, J.J Mitchell, P Cheng, C.-Y Wong, T.Y Cheung, C.M.G |
Keywords: | ARMS2 protein, human protein aged alcoholism cardiovascular disease cohort analysis female gene locus genetic predisposition genetics homozygote human incidence India macular degeneration male middle aged prevalence retrospective study risk factor Singapore time factor underweight Aged Alcoholism Cardiovascular Diseases Cohort Studies Female Genetic Loci Genetic Predisposition to Disease Homozygote Humans Incidence India Macular Degeneration Male Middle Aged Prevalence Proteins Retrospective Studies Risk Factors Singapore Thinness Time Factors |
Issue Date: | 2018 | Publisher: | Nature Publishing Group | Citation: | Foo, V.H.X, Yanagi, Y, Nguyen, Q.D, Sabanayagam, C, Lim, S.H, Neelam, K, Wang, J.J, Mitchell, P, Cheng, C.-Y, Wong, T.Y, Cheung, C.M.G (2018). Six-Year Incidence and Risk Factors of Age-Related Macular Degeneration in Singaporean. Scientific Reports 8 (1) : 8869. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-27202-w | Abstract: | We aimed to determine the 6-year incidence and risk factors of age-related macular degeneration (AMD) in first and second generations of Singaporean Indians. Baseline examination was conducted in 2007-9 and 6-year propsective follow-up examination of this Indian population in 2013-5. All participants underwent interviews with questionnaires and comprehensive medical and eye examinations. Incidence was age-standardized to Singaporean 2010 census. Risk factors associated with AMD incidence were assessed and compared between first and second generations of immigrants. Among 2200 persons who participated in the follow-up examination (75.5% response rate), gradable fundus photographs were available in 2105. The 6-year age-standardized incidences of early and late AMD were 5.26% and 0.51% respectively. Incident early AMD was associated with cardiovascular disease history (HR 1.59, 95% CI 1.04-2.45), underweight body mass index (BMI) (HR 3.12, 95% CI 1.37-7.14) (BMI of <18.5 vs 18.51-25 kg/m2), heavy alcohol drinking (HR 3.14 95% CI 1.25-7.89) and ARMS2 rs3750847 homozygous genetic loci carrier (HR 2.52, 95% CI 1.59-3.99). We found a relatively low incidence of early AMD in this Singaporean Indian population compared to Caucasian populations. Both first and second-generation Indian immigrants have similar incidence and risk factor patterns for early AMD. © 2018 The Author(s). | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/174215 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-27202-w |
Appears in Collections: | Elements Staff Publications |
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