Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-30177-3
Title: Forebrain medial septum sustains experimental neuropathic pain
Authors: Ariffin, M.Z 
Ibrahim, K.M 
Lee, A.T.-H 
Lee, R.Z
Poon, S.Y
Thong, H.K 
Liu, E.H.C 
Low, C.-M 
Khanna, S 
Keywords: alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid
glutamate receptor
glutamic acid
n methyl dextro aspartic acid receptor
animal
disease model
forebrain
male
medulla oblongata
metabolism
neuralgia
nociception
pain measurement
pathology
physiology
procedures
rat
septum nucleus
Sprague Dawley rat
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Animals
Disease Models, Animal
Glutamic Acid
Male
Medulla Oblongata
Neuralgia
Nociception
Pain Measurement
Prosencephalon
Rats
Rats, Sprague-Dawley
Receptors, Glutamate
Receptors, N-Methyl-D-Aspartate
Septal Nuclei
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Ariffin, M.Z, Ibrahim, K.M, Lee, A.T.-H, Lee, R.Z, Poon, S.Y, Thong, H.K, Liu, E.H.C, Low, C.-M, Khanna, S (2018). Forebrain medial septum sustains experimental neuropathic pain. Scientific Reports 8 (1) : 11892. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-30177-3
Abstract: The present study explored the role of the medial septal region (MS) in experimental neuropathic pain. For the first time, we found that the MS sustains nociceptive behaviors in rodent models of neuropathic pain, especially in the chronic constriction injury (CCI) model and the paclitaxel model of chemotherapy-induced neuropathic pain. For example, inactivation of the MS with intraseptal muscimol (2 ?g/?l, 0.5 ?l), a GABA mimetic, reversed peripheral hypersensitivity (PH) in the CCI model and induced place preference in a conditioned place preference task, a surrogate measure of spontaneous nociception. The effect of intraseptal muscimol on PH was comparable to that seen with microinjection of the local anesthetic, lidocaine, into rostral ventromedial medulla which is implicated in facilitating experimental chronic nociception. Cellular analysis in the CCI model showed that the MS region sustains nociceptive gain with CCI by facilitating basal nociceptive processing and the amplification of stimulus-evoked neural processing. Indeed, consistent with the idea that excitatory transmission through MS facilitates chronic experimental pain, intraseptal microinjection of antagonists acting at AMPA and NMDA glutamate receptors attenuated CCI-induced PH. We propose that the MS is a central monitor of bodily nociception which sustains molecular plasticity triggered by persistent noxious insult. © 2018, The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174213
ISSN: 2045-2322
DOI: 10.1038/s41598-018-30177-3
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_s41598-018-30177-3.pdf4.98 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

1
checked on Nov 26, 2020

Page view(s)

16
checked on Nov 27, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.