Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-33850-9
Title: High-Sensitivitycardiac Troponinsin Cardio-Healthy Subjects: A Cardiovascular Magnetic Resonance Imaging Study
Authors: Aw, T.-C
Huang, W.-T
Le, T.-T
Pua, C.-J
Ang, B
Phua, S.-K
Yeo, K.-K 
Cook, S.A 
Chin, C.W.L 
Keywords: biological marker
troponin I
troponin T
adolescent
adult
aged
blood
cardiovascular disease
female
follow up
human
male
middle aged
normal human
nuclear magnetic resonance imaging
procedures
prognosis
receiver operating characteristic
very elderly
young adult
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers
Cardiovascular Diseases
Female
Follow-Up Studies
Healthy Volunteers
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Prognosis
ROC Curve
Troponin I
Troponin T
Young Adult
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Aw, T.-C, Huang, W.-T, Le, T.-T, Pua, C.-J, Ang, B, Phua, S.-K, Yeo, K.-K, Cook, S.A, Chin, C.W.L (2018). High-Sensitivitycardiac Troponinsin Cardio-Healthy Subjects: A Cardiovascular Magnetic Resonance Imaging Study. Scientific Reports 8 (1) : 15409. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-33850-9
Abstract: The 99th percentile upper reference limits (URL) of high-sensitivity cardiac troponin (hs-cTn) in healthy subjects are essential for diagnosis and management of cardiovascular diseases. Unless screened stringently, subclinical disease affects the derived URL. In 779 healthy subjects(49% males; 17–88 years) screened by cardiovascular magnetic resonance (CMR), the gold standard for assessing cardiac volumes and myocardial mass; and estimated glomerular filtration rate (eGFR), the 99th percentile URL of hsTnT (Roche) and hs-cTnI (Abbott) were similar to the published URL. The overall 99th percentile URL of hsTnT and hsTnI were 15.2 and 21.2 ng/L, respectively; males had higher values than females (hsTnT: 16.8 versus 11.9 ng/L and hsTnI: 38.8 versus 14.4 ng/L). Correlation between hsTnT and hsTnI was modest (r = 0.45; p < 0.001). A larger proportion of healthy volunteers <60 years had detectable hsTnI compared to hsTnT (n = 534; 30.0% versus 18.3%, p < 0.001). Lower eGFR was an independent clinical determinant of hsTnT, but not hsTnI. Both hs-cTn concentrations were independently associated with myocardial mass and cardiac volumes (p < 0.01 for all), but only hsTnI was independently associated with CMR multi-directional strain measures and extent of LV trabeculations (p < 0.05 for all). Differences exist between hs-cTn assays and may influence their selection depending on cardiac conditions, patient population and local factors. © 2018, The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174201
ISSN: 2045-2322
DOI: 10.1038/s41598-018-33850-9
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