Please use this identifier to cite or link to this item: https://doi.org/10.1111/irv.12256
Title: Effectiveness of seasonal influenza vaccinations against laboratory-confirmed influenza-associated infections among Singapore military personnel in 2010-2013
Authors: Ho, H.P
Zhao, X 
Pang, J 
Chen, M.I..-C 
Lee, V.J.M 
Ang, L.W
Lin, R.V.T.P 
Gao, C.Q
Hsu, L.Y 
Cook, A.R 
Keywords: cyclic AMP
influenza vaccine
triple vaccine
influenza vaccine
adolescent
adult
army
Article
consultation
controlled study
drug efficacy
female
health program
human
influenza A (H1N1)
influenza A (H3N2)
influenza B
influenza vaccination
Influenza virus A H1N1
informed consent
laboratory
major clinical study
male
morbidity
priority journal
protection
reverse transcription polymerase chain reaction
risk assessment
seasonal influenza
Singapore
soldier
time series analysis
young adult
genetics
Influenza virus A
Influenza virus B
Influenza, Human
middle aged
physiology
season
soldier
statistics and numerical data
virology
Adolescent
Adult
Female
Humans
Influenza A virus
Influenza B virus
Influenza Vaccines
Influenza, Human
Male
Middle Aged
Military Personnel
Seasons
Singapore
Young Adult
Issue Date: 2014
Citation: Ho, H.P, Zhao, X, Pang, J, Chen, M.I..-C, Lee, V.J.M, Ang, L.W, Lin, R.V.T.P, Gao, C.Q, Hsu, L.Y, Cook, A.R (2014). Effectiveness of seasonal influenza vaccinations against laboratory-confirmed influenza-associated infections among Singapore military personnel in 2010-2013. Influenza and other Respiratory Viruses 8 (5) : 557-566. ScholarBank@NUS Repository. https://doi.org/10.1111/irv.12256
Abstract: Background: Limited information is available about seasonal influenza vaccine effectiveness (VE) in tropical communities. Objectives: Virus subtype-specific VE was determined for all military service personnel in the recruit camp and three other non-recruit camp in Singapore's Armed Forces from 1 June 2009 to 30 June 2012. Methods: Consenting servicemen underwent nasal washes, which were tested with RT-PCR and subtyped. The test positive case and test negative control design was used to estimate the VE. To estimate the overall effect of the programme on new recruits, we used an ecological time series approach. Results: A total of 7016 consultations were collected. The crude estimates for the VE of the triavalent vaccine against both influenza A(H1N1)pdm09 and influenza B were 84% (95% CI 78-88%, 79-86%, respectively). Vaccine efficacy against influenza A(H3N2) was markedly lower (VE 33%, 95% CI -4% to 57%). An estimated 70% (RR = 0·30; 95% CI 0·11-0·84), 39% (RR = 0·61;0·25-1·43) and 75% (RR = 0·25; 95% CI 0·11-0·50) reduction in the risk of influenza A(H1N1)pdm09, influenza A(H3N2) and influenza B infections, respectively, in the recruit camp during the post-vaccination period compared with during the pre-vaccination period was observed. Conclusions: Overall, the blanket influenza vaccine programme in Singapore's Armed Forces has had a moderate to high degree of protection against influenza A(H1N1)pdm09 and influenza B, but not against influenza A(H3N2). Blanket influenza vaccination is recommended for all military personnel. © 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
Source Title: Influenza and other Respiratory Viruses
URI: https://scholarbank.nus.edu.sg/handle/10635/174166
ISSN: 17502640
DOI: 10.1111/irv.12256
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