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Title: Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients
Authors: Tan, T.Z 
Miow, Q.H 
Miki, Y
Noda, T
Mori, S
Huang, R.Y.-J 
Thiery, J.P 
Keywords: antineoplastic agent
Breast Neoplasms
Colorectal Neoplasms
disease free survival
DNA microarray
drug effects
epithelial mesenchymal transition
gene expression regulation
Lung Neoplasms
Ovarian Neoplasms
Stomach Neoplasms
treatment outcome
tumor cell line
Urinary Bladder Neoplasms
Antineoplastic Agents
Breast Neoplasms
Cell Line, Tumor
Colorectal Neoplasms
Disease-Free Survival
Epithelial-Mesenchymal Transition
Gene Expression Regulation, Neoplastic
Lung Neoplasms
Oligonucleotide Array Sequence Analysis
Ovarian Neoplasms
Stomach Neoplasms
Treatment Outcome
Urinary Bladder Neoplasms
Issue Date: 2014
Citation: Tan, T.Z, Miow, Q.H, Miki, Y, Noda, T, Mori, S, Huang, R.Y.-J, Thiery, J.P (2014). Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients. EMBO Molecular Medicine 6 (10) : 1279-1293. ScholarBank@NUS Repository.
Abstract: Epithelial-mesenchymal transition (EMT) is a reversible and dynamic process hypothesized to be co-opted by carcinoma during invasion and metastasis. Yet, there is still no quantitative measure to assess the interplay between EMT and cancer progression. Here, we derived a method for universal EMT scoring from cancer-specific transcriptomic EMT signatures of ovarian, breast, bladder, lung, colorectal and gastric cancers. We show that EMT scoring exhibits good correlation with previously published, cancer-specific EMT signatures. This universal and quantitative EMT scoring was used to establish an EMT spectrum across various cancers, with good correlation noted between cell lines and tumours. We show correlations between EMT and poorer disease-free survival in ovarian and colorectal, but not breast, carcinomas, despite previous notions. Importantly, we found distinct responses between epithelial- and mesenchymal-like ovarian cancers to therapeutic regimes administered with or without paclitaxel in vivo and demonstrated that mesenchymal-like tumours do not always show resistance to chemotherapy. EMT scoring is thus a promising, versatile tool for the objective and systematic investigation of EMT roles and dynamics in cancer progression, treatment response and survival. © 2014 The Authors. Published under the terms of the CC BY 4.0 license.
Source Title: EMBO Molecular Medicine
ISSN: 17574676
DOI: 10.15252/emmm.201404208
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