Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.10096
Title: V?2+ and ?/? T cells show divergent trajectories during human aging
Authors: Ying Tan, C.T
Wistuba-Hamprecht, K
Xu, W
Zin Nyunt, M.S 
Vasudev, A
Kwong Lee, B.T
Pawelec, G
Puan, K.J
Rotzschke, O
Ng, T.P 
Larbi, A 
Keywords: CD27 antigen
CD28 antigen
gamma interferon
tumor necrosis factor alpha
lymphocyte antigen receptor
adaptive immunity
Article
CD4+ T lymphocyte
CD8+ T lymphocyte
cell aging
cytokine production
cytokine release
cytokine response
gamma delta T lymphocyte
immune response
immunosenescence
immunosurveillance
innate immunity
lymphocyte differentiation
lymphocyte subpopulation
memory cell
phenotype
protein expression
aged
female
human
immunology
male
middle aged
T lymphocyte subpopulation
very elderly
Aged
Aged, 80 and over
Female
Humans
Immunosenescence
Male
Middle Aged
Receptors, Antigen, T-Cell, alpha-beta
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocyte Subsets
Issue Date: 2016
Citation: Ying Tan, C.T, Wistuba-Hamprecht, K, Xu, W, Zin Nyunt, M.S, Vasudev, A, Kwong Lee, B.T, Pawelec, G, Puan, K.J, Rotzschke, O, Ng, T.P, Larbi, A (2016). V?2+ and ?/? T cells show divergent trajectories during human aging. Oncotarget 7 (29) : 44906-44918. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.10096
Abstract: Chronological aging and a variety of stressors are driving forces towards immunosenescence. While much attention was paid to the main T cell component, ?/? T cells, few studies concentrate on the impact of age on ?/? T cells' characteristics. The latter are important players of adaptive immunity but also have features associated with innate immunity. V?2+ are the main component of ?/? while V?1+ T cells expand upon Cytomegalovirus (CMV) infection and with age. The V?2+ T cells are not influenced by persistent infections but do contribute to immunosurveillance against bacterial pathogens. Here, we focus on V?2+ T cells and report that their composition and functionality is not altered in older adults. We have performed a side-by-side comparison of ?/? and V?2 cells by using two robust markers of T cell replicative history and cell differentiation (CD28 and CD27), and cytokine secretion (IFN-? and TNF-?). Significant differences in V?2 versus ?/? homeostasis, as well as phenotypic and functional changes emerged. However, the data strongly suggest a sustained functionality of the V?2 population with age, independently of the challenge. This suggests differential trajectories towards immunosenescence in ?/? and V?2+ T cells, most likely explained by their intrinsic functions.
Source Title: Oncotarget
URI: https://scholarbank.nus.edu.sg/handle/10635/174110
ISSN: 19492553
DOI: 10.18632/oncotarget.10096
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_18632_oncotarget_10096.pdf986.74 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

8
checked on Mar 3, 2021

Page view(s)

44
checked on Mar 5, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.