Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.8939
Title: Inflammatory and immune markers associated with physical frailty syndrome: Findings from Singapore longitudinal aging studies
Authors: Lu, Y
Ying Tan, C.T
Zin Nyunt, M.S 
Hei Mok, E.W
Camous, X
Kared, H
Fulop, T
Feng, L 
Ng, T.P 
Larbi, A
Keywords: CCL1 chemokine
CD14 antigen
CD16 antigen
CD27 antigen
CD28 antigen
CD3 antigen
CD38 antigen
CD4 antigen
CD45RA antigen
CXCL13 chemokine
gamma interferon
glycoprotein
interleukin 2 receptor alpha
interleukin 6 receptor
leptin
monocyte chemotactic protein 1
RANTES
soluble glycoprotein 130
tumor necrosis factor alpha
unclassified drug
adult
aged
aging
antigen expression
Article
B lymphocyte
CD38+ B lymphocyte
CD8+ T lymphocyte
cell aging
cell subpopulation
cellular immunity
clinical assessment tool
clinical feature
cohort analysis
community sample
controlled study
cytokine release
disease marker
disease severity
exploratory research
female
frail elderly
Frailty Index
functional disease
gamma delta T lymphocyte
human
immunocompetent cell
immunopathology
inflammation
longitudinal study
major clinical study
male
memory cell
monocyte
phenotype
physical disease
physical frailty syndrome
pilot study
prediction
serology
Singapore
syndrome
aging
frail elderly
frailty
immunology
inflammation
middle aged
Aged
Aging
Female
Frail Elderly
Frailty
Humans
Inflammation
Longitudinal Studies
Male
Middle Aged
Pilot Projects
Singapore
Issue Date: 2016
Citation: Lu, Y, Ying Tan, C.T, Zin Nyunt, M.S, Hei Mok, E.W, Camous, X, Kared, H, Fulop, T, Feng, L, Ng, T.P, Larbi, A (2016). Inflammatory and immune markers associated with physical frailty syndrome: Findings from Singapore longitudinal aging studies. Oncotarget 7 (20) : 28783-28795. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.8939
Abstract: Chronic systematic inflammation and reduced immune system fitness are considered potential contributing factors to the development of age-related frailty, but the underlying mechanisms are poorly defined. This exploratory study aimed to identify frailty-related inflammatory markers and immunological phenotypes in a cohort of community-dwelling adults aged ? 55 years. Frailty was assessed using two models, a Frailty Index and a categorical phenotype, and correlated with levels of circulating immune biomarkers and markers of senescence in immune cell subsets. We identified eight serological biomarkers that were associated with frailty, including sgp130, IL-2R?, I-309, MCP-1, BCA-1, RANTES, leptin, and IL-6R. Frailty Index was inversely predicted by the frequency of CD3+, CD45RA+, and central memory CD4 cells, and positively predicted by the loss of CD28 expression, especially in CD8+ T cells, while frailty status was predicted by the frequency of terminal effector CD8+ T cells. In ?/? T cells, frailty was negatively associated with CD27, and positively associated with IFN?+TNF?- secretion by ?/?2+ cells and IFN?-TNF?+ secretion by ?/?2- cells. Increased numbers of exhausted and CD38+ B cells, as well as CD14+CD16+ inflammatory monocytes, were also identified as frailty-associated phenotypes. This pilot study supports an association between inflammation, cellular immunity, and the process of frailty. These findings have significance for the early identification of frailty using circulating biomarkers prior to clinical manifestations of severe functional decline in the elderly.
Source Title: Oncotarget
URI: https://scholarbank.nus.edu.sg/handle/10635/174091
ISSN: 19492553
DOI: 10.18632/oncotarget.8939
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