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https://doi.org/10.3390/cancers8080073
| Title: | Developmental drift and the role of wnt signaling in aging | Authors: | Gruber J. Yee Z. Tolwinski N.S. |
Keywords: | beta catenin mammalian target of rapamycin nucleoredoxin reactive oxygen metabolite transcription factor FOXO transcription factor GATA unclassified drug Wnt protein aging Alzheimer disease bone regeneration carcinogenesis cell proliferation developmental drift theory elt 3 gene elt 5 gene elt 6 gene embryo development evolution gene gene function gene mutation homeostasis human klotho gene lifespan lin 44 gene longevity malignant neoplastic disease mom 2 gene nervous system development nonhuman osteoporosis oxidation reduction reaction oxidative stress pathogenesis phenotype pleiotropy protein function Review signal transduction sod 3 gene stem cell niche theory Wnt gene Wnt signaling pathway worm |
Issue Date: | 2016 | Citation: | Gruber J., Yee Z., Tolwinski N.S. (2016). Developmental drift and the role of wnt signaling in aging. Cancers 8 (8) : 73. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers8080073 | Abstract: | Population aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases exponentially, leading to large increases in public spending on healthcare. Here we summarize recent findings on the developmental drift theory of aging, and the links that have been established between aging and the Wnt signaling pathways. We focus on insights derived from model organisms connecting the evolutionary basis of aging and the link to developmental programming. © 2016 by the authors; licensee MDPI, Basel, Switzerland. | Source Title: | Cancers | URI: | https://scholarbank.nus.edu.sg/handle/10635/173998 | ISSN: | 20726694 | DOI: | 10.3390/cancers8080073 |
| Appears in Collections: | Elements Staff Publications |
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