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Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers8080073
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dc.titleDevelopmental drift and the role of wnt signaling in aging
dc.contributor.authorGruber J.
dc.contributor.authorYee Z.
dc.contributor.authorTolwinski N.S.
dc.date.accessioned2020-09-02T06:51:37Z
dc.date.available2020-09-02T06:51:37Z
dc.date.issued2016
dc.identifier.citationGruber J., Yee Z., Tolwinski N.S. (2016). Developmental drift and the role of wnt signaling in aging. Cancers 8 (8) : 73. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers8080073
dc.identifier.issn20726694
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/173998
dc.description.abstractPopulation aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases exponentially, leading to large increases in public spending on healthcare. Here we summarize recent findings on the developmental drift theory of aging, and the links that have been established between aging and the Wnt signaling pathways. We focus on insights derived from model organisms connecting the evolutionary basis of aging and the link to developmental programming. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
dc.sourceUnpaywall 20200831
dc.subjectbeta catenin
dc.subjectmammalian target of rapamycin
dc.subjectnucleoredoxin
dc.subjectreactive oxygen metabolite
dc.subjecttranscription factor FOXO
dc.subjecttranscription factor GATA
dc.subjectunclassified drug
dc.subjectWnt protein
dc.subjectaging
dc.subjectAlzheimer disease
dc.subjectbone regeneration
dc.subjectcarcinogenesis
dc.subjectcell proliferation
dc.subjectdevelopmental drift theory
dc.subjectelt 3 gene
dc.subjectelt 5 gene
dc.subjectelt 6 gene
dc.subjectembryo development
dc.subjectevolution
dc.subjectgene
dc.subjectgene function
dc.subjectgene mutation
dc.subjecthomeostasis
dc.subjecthuman
dc.subjectklotho gene
dc.subjectlifespan
dc.subjectlin 44 gene
dc.subjectlongevity
dc.subjectmalignant neoplastic disease
dc.subjectmom 2 gene
dc.subjectnervous system development
dc.subjectnonhuman
dc.subjectosteoporosis
dc.subjectoxidation reduction reaction
dc.subjectoxidative stress
dc.subjectpathogenesis
dc.subjectphenotype
dc.subjectpleiotropy
dc.subjectprotein function
dc.subjectReview
dc.subjectsignal transduction
dc.subjectsod 3 gene
dc.subjectstem cell niche
dc.subjecttheory
dc.subjectWnt gene
dc.subjectWnt signaling pathway
dc.subjectworm
dc.typeReview
dc.contributor.departmentYALE-NUS COLLEGE
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.3390/cancers8080073
dc.description.sourcetitleCancers
dc.description.volume8
dc.description.issue8
dc.description.page73
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