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Title: Transcription regulation of the human telomerase reverse transcriptase (hTERT) gene
Authors: Ramlee, M.K
Wang, J 
Toh, W.X
Li, S 
Keywords: colecalciferol receptor
early growth response factor 1
estrogen receptor
hypoxia inducible factor 2alpha
immunoglobulin enhancer binding protein
kruppel like factor 2
kruppel like factor 4
Myc protein
protein Mad1
STAT3 protein
STAT5 protein
telomerase reverse transcriptase
transcription factor
transcription factor AP 1
transcription factor CTCF
transcription factor E2F1
transcription factor NFX1
transcription factor PAX5
transcription factor PAX8
transcription factor Sp1
transcription factor Sp3
unclassified drug
upstream stimulatory factor 1
upstream stimulatory factor 2
3' untranslated region
binding site
cell differentiation
cellular distribution
chromosome rearrangement
DNA methylation
down regulation
gene expression regulation
gene location
gene mutation
gene regulatory network
histone modification
hTERT gene
nuclear reprogramming
pluripotent stem cell
promoter region
protein binding
protein DNA interaction
protein expression
protein localization
RNA stability
transcription regulation
Issue Date: 2016
Citation: Ramlee, M.K, Wang, J, Toh, W.X, Li, S (2016). Transcription regulation of the human telomerase reverse transcriptase (hTERT) gene. Genes 7 (8) : 50. ScholarBank@NUS Repository.
Abstract: Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their telomere length via expression of an enzymatic complex called telomerase. Similarly, more than 85%–90% of cancer cells are found to upregulate the expression of telomerase, conferring them with the potential to proliferate indefinitely. Telomerase Reverse Transcriptase (TERT), the catalytic subunit of telomerase holoenzyme, is the rate-limiting factor in reconstituting telomerase activity in vivo. To date, the expression and function of the human Telomerase Reverse Transcriptase (hTERT) gene are known to be regulated at various molecular levels (including genetic, mRNA, protein and subcellular localization) by a number of diverse factors. Among these means of regulation, transcription modulation is the most important, as evident in its tight regulation in cancer cell survival as well as pluripotent stem cell maintenance and differentiation. Here, we discuss how hTERT gene transcription is regulated, mainly focusing on the contribution of trans-acting factors such as transcription factors and epigenetic modifiers, as well as genetic alterations in hTERT proximal promoter. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
Source Title: Genes
ISSN: 20734425
DOI: 10.3390/genes7080050
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