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dc.titleTranscription regulation of the human telomerase reverse transcriptase (hTERT) gene
dc.contributor.authorRamlee, M.K
dc.contributor.authorWang, J
dc.contributor.authorToh, W.X
dc.contributor.authorLi, S
dc.identifier.citationRamlee, M.K, Wang, J, Toh, W.X, Li, S (2016). Transcription regulation of the human telomerase reverse transcriptase (hTERT) gene. Genes 7 (8) : 50. ScholarBank@NUS Repository.
dc.description.abstractEmbryonic stem cells and induced pluripotent stem cells have the ability to maintain their telomere length via expression of an enzymatic complex called telomerase. Similarly, more than 85%–90% of cancer cells are found to upregulate the expression of telomerase, conferring them with the potential to proliferate indefinitely. Telomerase Reverse Transcriptase (TERT), the catalytic subunit of telomerase holoenzyme, is the rate-limiting factor in reconstituting telomerase activity in vivo. To date, the expression and function of the human Telomerase Reverse Transcriptase (hTERT) gene are known to be regulated at various molecular levels (including genetic, mRNA, protein and subcellular localization) by a number of diverse factors. Among these means of regulation, transcription modulation is the most important, as evident in its tight regulation in cancer cell survival as well as pluripotent stem cell maintenance and differentiation. Here, we discuss how hTERT gene transcription is regulated, mainly focusing on the contribution of trans-acting factors such as transcription factors and epigenetic modifiers, as well as genetic alterations in hTERT proximal promoter. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
dc.sourceUnpaywall 20200831
dc.subjectcolecalciferol receptor
dc.subjectearly growth response factor 1
dc.subjectestrogen receptor
dc.subjecthypoxia inducible factor 2alpha
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectkruppel like factor 2
dc.subjectkruppel like factor 4
dc.subjectMyc protein
dc.subjectprotein Mad1
dc.subjectSTAT3 protein
dc.subjectSTAT5 protein
dc.subjecttelomerase reverse transcriptase
dc.subjecttranscription factor
dc.subjecttranscription factor AP 1
dc.subjecttranscription factor CTCF
dc.subjecttranscription factor E2F1
dc.subjecttranscription factor NFX1
dc.subjecttranscription factor PAX5
dc.subjecttranscription factor PAX8
dc.subjecttranscription factor Sp1
dc.subjecttranscription factor Sp3
dc.subjectunclassified drug
dc.subjectupstream stimulatory factor 1
dc.subjectupstream stimulatory factor 2
dc.subject3' untranslated region
dc.subjectbinding site
dc.subjectcell differentiation
dc.subjectcellular distribution
dc.subjectchromosome rearrangement
dc.subjectDNA methylation
dc.subjectdown regulation
dc.subjectgene expression regulation
dc.subjectgene location
dc.subjectgene mutation
dc.subjectgene regulatory network
dc.subjecthistone modification
dc.subjecthTERT gene
dc.subjectnuclear reprogramming
dc.subjectpluripotent stem cell
dc.subjectpromoter region
dc.subjectprotein binding
dc.subjectprotein DNA interaction
dc.subjectprotein expression
dc.subjectprotein localization
dc.subjectRNA stability
dc.subjecttranscription regulation
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
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