Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuroscience.2016.10.037
Title: ROLE OF PREFRONTAL CORTICAL CALCIUM-INDEPENDENT PHOSPHOLIPASE A(2) IN ANTINOCICEPTIVE EFFECT OF THE NOREPINEPHRINE REUPTAKE INHIBITOR ANTIDEPRESSSANT MAPROTILINE
Authors: Chew, Wee-Siong 
Suku-Maran, Shalini
Torta, Federico
Wenk, Markus R 
Stohler, Christian
Yeo, Jin-Fei 
Herr, Deron R 
Ong, Wei-Yi 
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
noradrenaline
prefrontal cortex
antinociception
lipid mediators
pain
DOCOSAHEXAENOIC ACID METABOLISM
FACIAL CARRAGEENAN INJECTION
SPINAL TRIGEMINAL NUCLEUS
PERIAQUEDUCTAL GRAY
NEUROPATHIC PAIN
ELECTRICAL-STIMULATION
THERAPEUTIC IMPORTANCE
INFLAMMATORY PAIN
NEUROPROTECTIN D1
CEREBRAL-CORTEX
Issue Date: 6-Jan-2017
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: Chew, Wee-Siong, Suku-Maran, Shalini, Torta, Federico, Wenk, Markus R, Stohler, Christian, Yeo, Jin-Fei, Herr, Deron R, Ong, Wei-Yi (2017-01-06). ROLE OF PREFRONTAL CORTICAL CALCIUM-INDEPENDENT PHOSPHOLIPASE A(2) IN ANTINOCICEPTIVE EFFECT OF THE NOREPINEPHRINE REUPTAKE INHIBITOR ANTIDEPRESSSANT MAPROTILINE. NEUROSCIENCE 340 : 91-100. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuroscience.2016.10.037
Abstract: © 2016 IBRO The prefrontal cortex is essential for executive functions such as decision-making and planning. There is also accumulating evidence that it is important for the modulation of pain. In this study, we investigated a possible role of prefrontal cortical calcium-independent phospholipase A2 (iPLA2) in antinociception induced by the norepinephrine reuptake inhibitor (NRI) and tetracyclic (tricyclic) antidepressant, maprotiline. Intraperitoneal injections of maprotiline increased iPLA2 mRNA and protein expression in the prefrontal cortex. This treatment also reduced grooming responses to von-Frey hair stimulation of the face after facial carrageenan injection, indicating decreased sensitivity to pain. The antinociceptive effect of maprotiline was abrogated by iPLA2 antisense oligonucleotide injection to the prefrontal cortex, indicating a role of this enzyme in antinociception. In contrast, injection of iPLA2 antisense oligonucleotide to the somatosensory cortex did not reduce the antinociceptive effect of maprotiline. Lipidomic analysis of the prefrontal cortex showed decrease in phosphatidylcholine species, but increase in lysophosphatidylcholine species, indicating increased PLA2 activity, and release of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) after maprotiline treatment. Differences in sphingomyelin/ceramide were also detected. These changes were not observed in maprotiline-treated mice that received iPLA2 antisense oligonucleotide to the prefrontal cortex. Metabolites of DHA and EPA may help to strengthen a known supraspinal antinociceptive pathway from the prefrontal cortex to the periaqueductal gray. Together, results indicate a role of prefrontal cortical iPLA2 and its enzymatic products in the antinociceptive effect of maprotiline.
Source Title: NEUROSCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/173206
ISSN: 03064522
18737544
DOI: 10.1016/j.neuroscience.2016.10.037
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