Please use this identifier to cite or link to this item:
Title: In utero infection of Zika virus leads to abnormal central nervous system development in mice
Authors: Zhang, W 
Tan, YW
Yam, WK 
Tu, H 
Qiu, L 
Tan, EK 
Chu, JJH 
Zeng, L 
Issue Date: 1-Dec-2019
Publisher: Nature Research
Citation: Zhang, W, Tan, YW, Yam, WK, Tu, H, Qiu, L, Tan, EK, Chu, JJH, Zeng, L (2019-12-01). In utero infection of Zika virus leads to abnormal central nervous system development in mice. Scientific Reports 9 (1) : 7298-. ScholarBank@NUS Repository.
Abstract: © 2019, The Author(s). The World Health Organization has declared ZIKA virus (ZIKV) a global public health emergency, prompted by the association of ZIKV infections with severe brain abnormalities in the human fetus. ZIKV preferentially targets human neuronal precursor cells (NPCs) in both monolayer and cortical brain organoid culture systems and stunts their growth. Although ZIKV is well recognized to cause microcephaly, there is no systematic analysis to demonstrate the effect of ZIKV on central nervous system (CNS) development, including brain malformations and spinal cord dysfunction. Here, we conducted a longitudinal analysis to show that a novel mouse model (infected in utero and monitored after birth until adulthood) recapitulates the effects of ZIKV infection affecting neural stem cells fate and leads to a thinner cortex and a smaller brain. Furthermore, we demonstrate the effect of ZIKV on spinal cord function. Specifically, we found significant reductions in neuron numbers in the anterior horn of grey matter of the spinal cord and muscle dystrophy with a significant decrease in forepaw grip strength in the ZIKV group. Thus, the established mouse model of ZIKV infection leading to abnormal CNS development will help to further advance our understanding of the disease pathogenesis.
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/s41598-019-43303-6
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
s41598-019-43303-6.pdfPublished version4 MBAdobe PDF




checked on Oct 19, 2020

Page view(s)

checked on Oct 15, 2020


checked on Oct 15, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.