Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11306-019-1621-3
Title: Serum lipidome analysis of healthy beagle dogs receiving different diets
Authors: Boretti, Felicitas S
Burla, Bo 
Deuel, Jeremy
Gao, Liang 
Wenk, Markus R 
Liesegang, Annette
Sieber-Ruckstuhl, Nadja S
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Canine
Mass spectrometry
Lipid metabolism
Fatty acids
PUFA
POLYUNSATURATED FATTY-ACIDS
VEGETABLE-OILS
DOUBLE-BLIND
FISH-OIL
SPHINGOSINE-1-PHOSPHATE
METABOLISM
RATIO
SPHINGOLIPIDS
TOCOPHEROL
SURVIVAL
Issue Date: 2019
Publisher: SPRINGER
Citation: Boretti, Felicitas S, Burla, Bo, Deuel, Jeremy, Gao, Liang, Wenk, Markus R, Liesegang, Annette, Sieber-Ruckstuhl, Nadja S (2019). Serum lipidome analysis of healthy beagle dogs receiving different diets. METABOLOMICS 16 (1). ScholarBank@NUS Repository. https://doi.org/10.1007/s11306-019-1621-3
Abstract: © 2019, The Author(s). Introduction: Food and dietary ingredients have significant effects on metabolism and health. Objective: To evaluate whether and how different diets affected the serum lipidomic profile of dogs. Methods: Sixteen healthy beagles were fed a commercial dry diet for 3 months (control diet). After an overnight fasting period, a blood sample was taken for serum lipidomic profile analysis, and each dog was then randomly assigned to one of two groups. Group 1 was fed a commercial diet (Diet 1) and group 2 was fed a self-made, balanced diet supplemented with linseed oil and salmon oil (Diet 2) for 3 months. After an overnight fasting period, a blood sample was taken from each dog. Serum cholesterol and triacylglycerol analyses were performed and the serum lipidomic profiles were analyzed using targeted liquid chromatography–mass spectrometry. Results: Dogs fed the supplemented self-made diet (Diet 2) had significantly higher omega-3 fatty acid-containing lipids species and significantly lower saturated and mono- and di-unsaturated lipid species. Concentrations of sphingosine 1-phosphate species S1P d16:1 and S1P d17:1 were significantly increased after feeding Diet 2. Conclusion: This study found that different diets had significant effects on the dog’s serum lipidomic profile. Therefore, in studies that include lipidomic analyses, diet should be included as a confounding factor.
Source Title: METABOLOMICS
URI: https://scholarbank.nus.edu.sg/handle/10635/170639
ISSN: 15733882
15733890
DOI: 10.1007/s11306-019-1621-3
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