Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11306-019-1621-3
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dc.titleSerum lipidome analysis of healthy beagle dogs receiving different diets
dc.contributor.authorBoretti, Felicitas S
dc.contributor.authorBurla, Bo
dc.contributor.authorDeuel, Jeremy
dc.contributor.authorGao, Liang
dc.contributor.authorWenk, Markus R
dc.contributor.authorLiesegang, Annette
dc.contributor.authorSieber-Ruckstuhl, Nadja S
dc.date.accessioned2020-06-22T07:21:08Z
dc.date.available2020-06-22T07:21:08Z
dc.date.issued2019
dc.identifier.citationBoretti, Felicitas S, Burla, Bo, Deuel, Jeremy, Gao, Liang, Wenk, Markus R, Liesegang, Annette, Sieber-Ruckstuhl, Nadja S (2019). Serum lipidome analysis of healthy beagle dogs receiving different diets. METABOLOMICS 16 (1). ScholarBank@NUS Repository. https://doi.org/10.1007/s11306-019-1621-3
dc.identifier.issn15733882
dc.identifier.issn15733890
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/170639
dc.description.abstract© 2019, The Author(s). Introduction: Food and dietary ingredients have significant effects on metabolism and health. Objective: To evaluate whether and how different diets affected the serum lipidomic profile of dogs. Methods: Sixteen healthy beagles were fed a commercial dry diet for 3 months (control diet). After an overnight fasting period, a blood sample was taken for serum lipidomic profile analysis, and each dog was then randomly assigned to one of two groups. Group 1 was fed a commercial diet (Diet 1) and group 2 was fed a self-made, balanced diet supplemented with linseed oil and salmon oil (Diet 2) for 3 months. After an overnight fasting period, a blood sample was taken from each dog. Serum cholesterol and triacylglycerol analyses were performed and the serum lipidomic profiles were analyzed using targeted liquid chromatography–mass spectrometry. Results: Dogs fed the supplemented self-made diet (Diet 2) had significantly higher omega-3 fatty acid-containing lipids species and significantly lower saturated and mono- and di-unsaturated lipid species. Concentrations of sphingosine 1-phosphate species S1P d16:1 and S1P d17:1 were significantly increased after feeding Diet 2. Conclusion: This study found that different diets had significant effects on the dog’s serum lipidomic profile. Therefore, in studies that include lipidomic analyses, diet should be included as a confounding factor.
dc.language.isoen
dc.publisherSPRINGER
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectEndocrinology & Metabolism
dc.subjectCanine
dc.subjectMass spectrometry
dc.subjectLipid metabolism
dc.subjectFatty acids
dc.subjectPUFA
dc.subjectPOLYUNSATURATED FATTY-ACIDS
dc.subjectVEGETABLE-OILS
dc.subjectDOUBLE-BLIND
dc.subjectFISH-OIL
dc.subjectSPHINGOSINE-1-PHOSPHATE
dc.subjectMETABOLISM
dc.subjectRATIO
dc.subjectSPHINGOLIPIDS
dc.subjectTOCOPHEROL
dc.subjectSURVIVAL
dc.typeArticle
dc.date.updated2020-06-17T04:54:41Z
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.1007/s11306-019-1621-3
dc.description.sourcetitleMETABOLOMICS
dc.description.volume16
dc.description.issue1
dc.published.statePublished
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