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https://doi.org/10.1021/acs.orglett.8b02519
| Title: | Phosphine-Catalyzed Formal Oxa-[4+2] Annulation Employing Nitroethylene and Enones: Enantioselective Synthesis of Dihydropyrans | Authors: | Jin, Zhichao Ni, Huanzhen Zhou, Bo Zheng, Wenrui Yixin, Lu |
Keywords: | Science & Technology Physical Sciences Chemistry, Organic Chemistry ELECTRON-DEFICIENT OLEFINS ALPHA-AMINO-ACID NATURAL-PRODUCTS ALPHA,BETA-UNSATURATED IMINES FUNCTIONALIZED CYCLOPENTENES ASYMMETRIC-SYNTHESIS POLYKETIDE SYNTHASE 3+2 CYCLOADDITIONS POLYCYCLIC ETHERS GAMMA-ADDITIONS |
Issue Date: | 7-Sep-2018 | Publisher: | AMER CHEMICAL SOC | Citation: | Jin, Zhichao, Ni, Huanzhen, Zhou, Bo, Zheng, Wenrui, Yixin, Lu (2018-09-07). Phosphine-Catalyzed Formal Oxa-[4+2] Annulation Employing Nitroethylene and Enones: Enantioselective Synthesis of Dihydropyrans. ORGANIC LETTERS 20 (17) : 5515-5518. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.orglett.8b02519 | Abstract: | © 2018 American Chemical Society. The first phosphine-catalyzed enantioselective formal oxa-[4 + 2] reaction between nitroethylene and α-cyano-α,β-unsaturated ketones has been developed. In the presence of a dipeptide-based phosphine catalyst and achiral Brønsted acid additives, highly functionalized 3,4-dihydro-2H-pyrans were obtained with excellent enantio- and diastereoselectivities. | Source Title: | ORGANIC LETTERS | URI: | https://scholarbank.nus.edu.sg/handle/10635/170220 | ISSN: | 1523-7060,1523-7052 | DOI: | 10.1021/acs.orglett.8b02519 |
| Appears in Collections: | Staff Publications Elements |
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| [1] OL-2018-02519t._revised.pdf | Accepted version | 899.42 kB | Adobe PDF | OPEN | Post-print | View/Download |
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