Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsami.8b01960
Title: Artemisinin and AlEgen Conjugate for Mitochondria-Targeted and Image-Guided Chemo- and Photodynamic Cancer Cell Ablation
Authors: Feng, Guangxue 
Liu, Jie 
Zhang, Chong-Jing 
Liu, Bin 
Keywords: Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
Artemisinin
Mitochondrial targeting
Fluorescence imaging
Photodynamic therapy
Combination cancer therapy
AGGREGATION-INDUCED-EMISSION
TRADITIONAL CHINESE MEDICINE
NF-KAPPA-B
SINGLET OXYGEN
AIE CHARACTERISTICS
THERAPY
PROBE
PHOTOSENSITIZERS
NANOPARTICLES
THERANOSTICS
Issue Date: 11-Apr-2018
Publisher: AMERICAN CHEMICAL SOCIETY
Citation: Feng, Guangxue, Liu, Jie, Zhang, Chong-Jing, Liu, Bin (2018-04-11). Artemisinin and AlEgen Conjugate for Mitochondria-Targeted and Image-Guided Chemo- and Photodynamic Cancer Cell Ablation. ACS APPLIED MATERIALS & INTERFACES 10 (14) : 11546-11553. ScholarBank@NUS Repository. https://doi.org/10.1021/acsami.8b01960
Abstract: © 2018 American Chemical Society. Cell organelle targeting is a promising approach for cancer therapy. We herein report a light-up probe (tetraphenylethenethiophene (TPETH)-Mito-1ART) to co-deliver artemisinin (ART) and an aggregation-induced emission (AIE) photosensitizer to cancer cell mitochondria for image-guided combination cancer cell ablation. This probe contains a TPETH core, two mitochondria targeting arms with ART on one arm, which show high specificity toward cancer cells over normal ones, predominant accumulation, and fluorescence turn-on in mitochondria. The fresh heme produced in mitochondria quickly activates ART, and the direct generation of reactive oxygen species at mitochondria promotes photodynamic therapy (PDT) performance. The incorporation of ART and PDT leads to a largely improved cancer cell ablation efficacy with a synergistic effect, which could quickly depolarize mitochondrial membrane and largely reduce cancer migration activity. This co-delivery strategy provides great potentials for subcellular organelle-targeted and image-guided combination cancer cell ablation.
Source Title: ACS APPLIED MATERIALS & INTERFACES
URI: https://scholarbank.nus.edu.sg/handle/10635/169764
ISSN: 19448244
19448252
DOI: 10.1021/acsami.8b01960
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