Please use this identifier to cite or link to this item: https://doi.org/10.1039/c6tb01159d
Title: Decoration of porphyrin with tetraphenylethene: converting a fluorophore with aggregation-caused quenching to aggregation-induced emission enhancement
Authors: GUO BING 
CAI XIAOLEI 
XU SHIDANG 
Fateminia, Syed Mohammad Ali
LIU JIE 
LIANG JING 
FENG GUANGXUE 
Wu, Wenbo
LIU BIN 
Keywords: Science & Technology
Technology
Materials Science, Biomaterials
Materials Science
FLUORESCENT ORGANIC NANOPARTICLES
PHOTODYNAMIC THERAPY
IN-VIVO
PROTOPORPHYRIN-IX
DRUG-DELIVERY
OXYGEN
MICELLES
RESECTION
COPOLYMER
HYDROGEL
Issue Date: 1-Jan-2016
Publisher: Royal Society of Chemistry
Citation: GUO BING, CAI XIAOLEI, XU SHIDANG, Fateminia, Syed Mohammad Ali, LIU JIE, LIANG JING, FENG GUANGXUE, Wu, Wenbo, LIU BIN (2016-01-01). Decoration of porphyrin with tetraphenylethene: converting a fluorophore with aggregation-caused quenching to aggregation-induced emission enhancement. Journal of Materials Chemistry B 4 (27) : 4690-4695. ScholarBank@NUS Repository. https://doi.org/10.1039/c6tb01159d
Abstract: Porphyrins have long been used as fluorescence imaging contrast agents. However, they often suffer from aggregation-caused quenching (ACQ) which limits their maximal imaging ability. It is desirable to design new porphyrin derivatives exhibiting aggregation induced emission enhancement (AIEE) with a high photoluminescence (PL) intensity in an aggregated state. Herein, we transform porphyrin from an ACQ molecule to an AIEE one by simply decorating a porphyrin core with four tetraphenylethene arms. We further encapsulate the new AIE porphyrin into nanoparticles and examine their fluorescence imaging in vitro with HeLa cells. This research demonstrates a general approach to produce AIEE porphyrin derivatives that could potentially enhance their performance in various areas.
Source Title: Journal of Materials Chemistry B
URI: https://scholarbank.nus.edu.sg/handle/10635/169673
ISSN: 2050-750X
2050-7518
DOI: 10.1039/c6tb01159d
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