Please use this identifier to cite or link to this item: https://doi.org/10.1002/advs.201600407
Title: Ultrasmall Conjugated Polymer Nanoparticles with High Specificity for Targeted Cancer Cell Imaging
Authors: FENG GUANGXUE 
LIU JIE 
Liu, Rongrong
MAO DUO 
Tomczak, Nikodem
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
cancer targeting
conjugated polymers
fluorescence imaging
organic nanoparticles
IN-VIVO
GOLD NANOPARTICLES
QUANTUM DOTS
DRUG-DELIVERY
PARTICLE-SIZE
ENDOCYTOSIS
THERAPY
CYTOTOXICITY
NANOSCALE
PLATFORM
Issue Date: 1-Sep-2017
Publisher: Wiley-VCH Verlag
Citation: FENG GUANGXUE, LIU JIE, Liu, Rongrong, MAO DUO, Tomczak, Nikodem, LIU BIN (2017-09-01). Ultrasmall Conjugated Polymer Nanoparticles with High Specificity for Targeted Cancer Cell Imaging. Advanced Science 4 (9). ScholarBank@NUS Repository. https://doi.org/10.1002/advs.201600407
Abstract: Fluorescent and biocompatible organic nanoparticles have attracted great interest in cancer detection and imaging, but the nonspecific cellular uptake has limited the detection specificity and sensitivity. Herein, the authors report the ultrasmall conjugated polymer nanoparticles (CPNs) with bright far-red/near-infrared emission for targeted cancer imaging with high specificity. The sizes of the ultrasmall CPNs are around 6 nm (CPN6), while large CPNs show sizes around 30 nm (CPN30). Moreover, CPN6 exhibits largely improved fluorescence quantum yield (η) of 41% than CPN30 (25%). Benefiting from the ultrasmall size, bare CPN6 shows largely suppressed nonspecific cellular uptake as compared to CPN30, while cyclic arginine-glycine-aspartic acid (cRGD) functionalized CPN6 (cRGD-CPN6) possesses excellent selectivity toward αvβ3 integrin overexpressed MDA-MB-231 cells over other cells in cell mixtures. The faster body clearance of CPN6 over CPN30 indicates its greater potentials as a noninvasive nanoprobe for in vivo and practical applications.
Source Title: Advanced Science
URI: https://scholarbank.nus.edu.sg/handle/10635/169667
ISSN: 2198-3844
2198-3844
DOI: 10.1002/advs.201600407
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