Please use this identifier to cite or link to this item: https://doi.org/10.1002/advs.201600407
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dc.titleUltrasmall Conjugated Polymer Nanoparticles with High Specificity for Targeted Cancer Cell Imaging
dc.contributor.authorFENG GUANGXUE
dc.contributor.authorLIU JIE
dc.contributor.authorLiu, Rongrong
dc.contributor.authorMAO DUO
dc.contributor.authorTomczak, Nikodem
dc.contributor.authorLIU BIN
dc.date.accessioned2020-06-11T07:39:51Z
dc.date.available2020-06-11T07:39:51Z
dc.date.issued2017-09-01
dc.identifier.citationFENG GUANGXUE, LIU JIE, Liu, Rongrong, MAO DUO, Tomczak, Nikodem, LIU BIN (2017-09-01). Ultrasmall Conjugated Polymer Nanoparticles with High Specificity for Targeted Cancer Cell Imaging. Advanced Science 4 (9). ScholarBank@NUS Repository. https://doi.org/10.1002/advs.201600407
dc.identifier.issn2198-3844
dc.identifier.issn2198-3844
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169667
dc.description.abstractFluorescent and biocompatible organic nanoparticles have attracted great interest in cancer detection and imaging, but the nonspecific cellular uptake has limited the detection specificity and sensitivity. Herein, the authors report the ultrasmall conjugated polymer nanoparticles (CPNs) with bright far-red/near-infrared emission for targeted cancer imaging with high specificity. The sizes of the ultrasmall CPNs are around 6 nm (CPN6), while large CPNs show sizes around 30 nm (CPN30). Moreover, CPN6 exhibits largely improved fluorescence quantum yield (η) of 41% than CPN30 (25%). Benefiting from the ultrasmall size, bare CPN6 shows largely suppressed nonspecific cellular uptake as compared to CPN30, while cyclic arginine-glycine-aspartic acid (cRGD) functionalized CPN6 (cRGD-CPN6) possesses excellent selectivity toward αvβ3 integrin overexpressed MDA-MB-231 cells over other cells in cell mixtures. The faster body clearance of CPN6 over CPN30 indicates its greater potentials as a noninvasive nanoprobe for in vivo and practical applications.
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Multidisciplinary
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectChemistry
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.subjectcancer targeting
dc.subjectconjugated polymers
dc.subjectfluorescence imaging
dc.subjectorganic nanoparticles
dc.subjectIN-VIVO
dc.subjectGOLD NANOPARTICLES
dc.subjectQUANTUM DOTS
dc.subjectDRUG-DELIVERY
dc.subjectPARTICLE-SIZE
dc.subjectENDOCYTOSIS
dc.subjectTHERAPY
dc.subjectCYTOTOXICITY
dc.subjectNANOSCALE
dc.subjectPLATFORM
dc.typeArticle
dc.date.updated2020-06-10T08:54:17Z
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.description.doi10.1002/advs.201600407
dc.description.sourcetitleAdvanced Science
dc.description.volume4
dc.description.issue9
dc.published.statePublished
dc.grant.idR279-000-443-281
dc.grant.idR279-000-482-133
dc.grant.fundingagencyNational Research Foundation Singapore
dc.grant.fundingagencyNational University of Singapore
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