Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.201707519
Title: Metal-Organic Framework as a Simple and General Inert Nanocarrier for Photosensitizers to Implement Activatable Photodynamic Therapy
Authors: Hu, Fang
MAO DUO 
KENRY 
WANG YUXIANG 
Wu, Wenbo
Zhao Dan 
Kong, Deling
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
activatable photosensitizers
aggregation-induced emission
hydrogen peroxide
MIL-100 (Fe)
oxygen
AGGREGATION-INDUCED EMISSION
DRUG-DELIVERY
CANCER-CELLS
HIGHLY EFFICIENT
SOLID TUMORS
NANOPARTICLES
BIOPROBE
ABLATION
PLATFORM
HYPOXIA
Issue Date: 9-May-2018
Publisher: Wiley-VCH Verlag
Citation: Hu, Fang, MAO DUO, KENRY, WANG YUXIANG, Wu, Wenbo, Zhao Dan, Kong, Deling, LIU BIN (2018-05-09). Metal-Organic Framework as a Simple and General Inert Nanocarrier for Photosensitizers to Implement Activatable Photodynamic Therapy. Advanced Functional Materials 28 (19). ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.201707519
Abstract: There has been a surging interest in the synthesis of activatable photosensitizers (PSs) as they can be selectively activated with minimum nonspecific phototoxic damages for photodynamic therapy (PDT). Conventional strategies to realize activatable PSs are only applicable to a limited number of molecules. Herein, a simple and general strategy to yield activatable PSs by coupling MIL-100 (Fe) (MIL: Materials Institute Lavoisier) with different kinds of PSs is presented. Specifically, when PSs are encapsulated into MIL-100 (Fe), the photosensitization capability is suppressed due to their isolation from O2. After the reaction between iron(III) in MIL-100 (Fe) and H2O2 occurs, the framework of MIL-100 (Fe) collapses and the encapsulated PSs regain contact with O2, leading to activation of photosensitization. In addition, the decomposition of H2O2 can generate O2 to relieve tumor hypoxia and enhance PDT effect. As O2 is an indispensable factor for PDT, the activation strategy should be generally applicable to different PSs for activatable PDT.
Source Title: Advanced Functional Materials
URI: https://scholarbank.nus.edu.sg/handle/10635/169657
ISSN: 1616-301X
1616-3028
DOI: 10.1002/adfm.201707519
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