Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.201707519
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dc.titleMetal-Organic Framework as a Simple and General Inert Nanocarrier for Photosensitizers to Implement Activatable Photodynamic Therapy
dc.contributor.authorHu, Fang
dc.contributor.authorMAO DUO
dc.contributor.authorKENRY
dc.contributor.authorWANG YUXIANG
dc.contributor.authorWu, Wenbo
dc.contributor.authorZhao Dan
dc.contributor.authorKong, Deling
dc.contributor.authorLIU BIN
dc.date.accessioned2020-06-11T04:50:04Z
dc.date.available2020-06-11T04:50:04Z
dc.date.issued2018-05-09
dc.identifier.citationHu, Fang, MAO DUO, KENRY, WANG YUXIANG, Wu, Wenbo, Zhao Dan, Kong, Deling, LIU BIN (2018-05-09). Metal-Organic Framework as a Simple and General Inert Nanocarrier for Photosensitizers to Implement Activatable Photodynamic Therapy. Advanced Functional Materials 28 (19). ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.201707519
dc.identifier.issn1616-301X
dc.identifier.issn1616-3028
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169657
dc.description.abstractThere has been a surging interest in the synthesis of activatable photosensitizers (PSs) as they can be selectively activated with minimum nonspecific phototoxic damages for photodynamic therapy (PDT). Conventional strategies to realize activatable PSs are only applicable to a limited number of molecules. Herein, a simple and general strategy to yield activatable PSs by coupling MIL-100 (Fe) (MIL: Materials Institute Lavoisier) with different kinds of PSs is presented. Specifically, when PSs are encapsulated into MIL-100 (Fe), the photosensitization capability is suppressed due to their isolation from O2. After the reaction between iron(III) in MIL-100 (Fe) and H2O2 occurs, the framework of MIL-100 (Fe) collapses and the encapsulated PSs regain contact with O2, leading to activation of photosensitization. In addition, the decomposition of H2O2 can generate O2 to relieve tumor hypoxia and enhance PDT effect. As O2 is an indispensable factor for PDT, the activation strategy should be generally applicable to different PSs for activatable PDT.
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry, Physical
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectPhysics, Applied
dc.subjectPhysics, Condensed Matter
dc.subjectChemistry
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.subjectPhysics
dc.subjectactivatable photosensitizers
dc.subjectaggregation-induced emission
dc.subjecthydrogen peroxide
dc.subjectMIL-100 (Fe)
dc.subjectoxygen
dc.subjectAGGREGATION-INDUCED EMISSION
dc.subjectDRUG-DELIVERY
dc.subjectCANCER-CELLS
dc.subjectHIGHLY EFFICIENT
dc.subjectSOLID TUMORS
dc.subjectNANOPARTICLES
dc.subjectBIOPROBE
dc.subjectABLATION
dc.subjectPLATFORM
dc.subjectHYPOXIA
dc.typeArticle
dc.date.updated2020-06-10T08:37:05Z
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.description.doi10.1002/adfm.201707519
dc.description.sourcetitleAdvanced Functional Materials
dc.description.volume28
dc.description.issue19
dc.published.statePublished
dc.grant.idR279-000-444-281
dc.grant.idR279-000-483-281
dc.grant.idR279-000-482-133
dc.grant.fundingagencyNational Research Foundation Singapore
dc.grant.fundingagencyNational University of Singapore
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