Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201809641
Title: Multifunctional Liposome: A Bright AIEgen-Lipid Conjugate with Strong Photosensitization
Authors: CAI XIAOLEI 
MAO DUO 
WANG CAN 
Kong, Deling
Cheng, Xiamin
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
aggregation-induced emission
antitumor therapy
fluorescence imaging
liposomes
photodynamic therapy
AGGREGATION-INDUCED EMISSION
PHOTODYNAMIC ABLATION
THERANOSTIC LIPOSOMES
DELIVERY
VESICLES
PEPTIDE
Issue Date: 10-Dec-2018
Publisher: Wiley-VCH Verlag
Citation: CAI XIAOLEI, MAO DUO, WANG CAN, Kong, Deling, Cheng, Xiamin, LIU BIN (2018-12-10). Multifunctional Liposome: A Bright AIEgen-Lipid Conjugate with Strong Photosensitization. Angewandte Chemie - International Edition 57 (50) : 16396-16400. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201809641
Abstract: Liposomes have been used as popular drug delivery systems for cancer therapy. However, it is difficult to track traditional liposome delivery systems in an efficient and stable fashion to assess their delivery efficacy and biodistribution after administration. Meanwhile, conventional fluorescent liposomes containing optical tracers face the challenge of aggregation-caused quenching. Herein, we report a strategy for the integration of an aggregation-induced emission fluorogen with a liposome to yield an AIEgen–lipid conjugate, termed “AIEsome”. The AIEsome exhibits bright red fluorescence along with great photostability and biocompatibility, and can be used for in vitro cancer cell labeling and in vivo tumor targeting. Meanwhile, benefiting from the excellent photosensitizing ability of the AIEgen and its good oxygen exposure in aqueous media, the AIEsome also performs well in efficient photodynamic therapy (PDT) for both in vitro cancer cell ablation and in vivo antitumor therapy after white light illumination.
Source Title: Angewandte Chemie - International Edition
URI: https://scholarbank.nus.edu.sg/handle/10635/169653
ISSN: 1433-7851
1521-3773
DOI: 10.1002/anie.201809641
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