Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201809641
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dc.titleMultifunctional Liposome: A Bright AIEgen-Lipid Conjugate with Strong Photosensitization
dc.contributor.authorCAI XIAOLEI
dc.contributor.authorMAO DUO
dc.contributor.authorWANG CAN
dc.contributor.authorKong, Deling
dc.contributor.authorCheng, Xiamin
dc.contributor.authorLIU BIN
dc.date.accessioned2020-06-11T03:14:46Z
dc.date.available2020-06-11T03:14:46Z
dc.date.issued2018-12-10
dc.identifier.citationCAI XIAOLEI, MAO DUO, WANG CAN, Kong, Deling, Cheng, Xiamin, LIU BIN (2018-12-10). Multifunctional Liposome: A Bright AIEgen-Lipid Conjugate with Strong Photosensitization. Angewandte Chemie - International Edition 57 (50) : 16396-16400. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201809641
dc.identifier.issn1433-7851
dc.identifier.issn1521-3773
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169653
dc.description.abstractLiposomes have been used as popular drug delivery systems for cancer therapy. However, it is difficult to track traditional liposome delivery systems in an efficient and stable fashion to assess their delivery efficacy and biodistribution after administration. Meanwhile, conventional fluorescent liposomes containing optical tracers face the challenge of aggregation-caused quenching. Herein, we report a strategy for the integration of an aggregation-induced emission fluorogen with a liposome to yield an AIEgen–lipid conjugate, termed “AIEsome”. The AIEsome exhibits bright red fluorescence along with great photostability and biocompatibility, and can be used for in vitro cancer cell labeling and in vivo tumor targeting. Meanwhile, benefiting from the excellent photosensitizing ability of the AIEgen and its good oxygen exposure in aqueous media, the AIEsome also performs well in efficient photodynamic therapy (PDT) for both in vitro cancer cell ablation and in vivo antitumor therapy after white light illumination.
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry
dc.subjectaggregation-induced emission
dc.subjectantitumor therapy
dc.subjectfluorescence imaging
dc.subjectliposomes
dc.subjectphotodynamic therapy
dc.subjectAGGREGATION-INDUCED EMISSION
dc.subjectPHOTODYNAMIC ABLATION
dc.subjectTHERANOSTIC LIPOSOMES
dc.subjectDELIVERY
dc.subjectVESICLES
dc.subjectPEPTIDE
dc.typeArticle
dc.date.updated2020-06-10T08:27:43Z
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.description.doi10.1002/anie.201809641
dc.description.sourcetitleAngewandte Chemie - International Edition
dc.description.volume57
dc.description.issue50
dc.description.page16396-16400
dc.published.statePublished
dc.grant.idR279-000-444-281
dc.grant.idR279-000-483-281
dc.grant.fundingagencyNational Research Foundation Singapore
dc.grant.fundingagencyNational University of Singapore
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