Please use this identifier to cite or link to this item: https://doi.org/10.1039/c5sc03583j
Title: A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
Authors: YUAN YOUYONG 
Zhang Chongjing 
XU SHIDANG 
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
AGGREGATION-INDUCED-EMISSION
BIOMEDICAL APPLICATIONS
MAGNETIC-RESONANCE
THERANOSTIC AGENTS
REACTIVE OXYGEN
DRUG-RELEASE
FAR-RED
THERAPY
LIGHT
PRODRUG
Issue Date: 1-Mar-2016
Publisher: Royal Society of Chemistry (RSC)
Citation: YUAN YOUYONG, Zhang Chongjing, XU SHIDANG, LIU BIN (2016-03-01). A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells. Chemical Science 7 (3) : 1862-1866. ScholarBank@NUS Repository. https://doi.org/10.1039/c5sc03583j
Abstract: The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated via a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emits red fluorescence in water, and the red emissive PS can be used for probe self-tracking. Upon image-guided light irradiation, the generated singlet oxygen cleaves the AA linker to yield green fluorescence turn-on of rhodol, which offers real-time and in situ monitoring of singlet oxygen generation during photodynamic ablation of cancer cells, providing a strategy for the early evaluation of the therapeutic effect.
Source Title: Chemical Science
URI: https://scholarbank.nus.edu.sg/handle/10635/169644
ISSN: 2041-6520
2041-6539
DOI: 10.1039/c5sc03583j
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