Please use this identifier to cite or link to this item:
https://doi.org/10.1021/acs.chemmater.8b01320
Title: | ONOO- and ClO- Responsive Organic Nanoparticles for Specific in Vivo Image-Guided Photodynamic Bacterial Ablation | Authors: | Wu, Wenbo Mao, Duo Cai, Xiaolei Duan, Yukun Hu, Fang Kong, Deling Liu, Bin |
Keywords: | Science & Technology Physical Sciences Technology Chemistry, Physical Materials Science, Multidisciplinary Chemistry Materials Science AGGREGATION-INDUCED EMISSION THERAPY PROBE PHOTOSENSITIZERS PEROXYNITRITE INACTIVATION NANOPROBE AIE |
Issue Date: | 12-Jun-2018 | Publisher: | AMER CHEMICAL SOCIETY | Citation: | Wu, Wenbo, Mao, Duo, Cai, Xiaolei, Duan, Yukun, Hu, Fang, Kong, Deling, Liu, Bin (2018-06-12). ONOO- and ClO- Responsive Organic Nanoparticles for Specific in Vivo Image-Guided Photodynamic Bacterial Ablation. CHEMISTRY OF MATERIALS 30 (11) : 3867-3873. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.chemmater.8b01320 | Abstract: | Copyright © 2018 American Chemical Society. Bacterial infection poses serious medical and public concerns. Herein, "33%IRTP" nanoparticles (NPs) are reported for in vivo bacterial infection detection and photodynamic treatment, serving as an alternative to antibiotic therapy. 33%IRTP nanoparticles have been developed by self-assembly of an ONOO- and ClO- responsive near-infrared dye "IR786S" and an amphiphilic polymer "TBD-PEG" containing a highly effective photosensitizer with aggregation-induced emission characteristics. As an energy acceptor, IR786S not only shows near-infrared emission for fluorescence imaging but also quenches both fluorescence and singlet oxygen generation of TBD-PEG, thus eliminating the phototoxicity of 33%IRTP nanoparticles in normal tissues. Once 33%IRTP NPs reach bacterial infection sites, IR786S could be decomposed by the overexpressed ONOO- and ClO- to turn on the red fluorescence and singlet oxygen generation of TBD-PEG, which offers image-guided photodynamic bacterial ablation. Considering their negligible in vivo dark toxicity, 33%IRTP nanoparticles demonstrate great potential in antibacterial applications. | Source Title: | CHEMISTRY OF MATERIALS | URI: | https://scholarbank.nus.edu.sg/handle/10635/169540 | ISSN: | 08974756 15205002 |
DOI: | 10.1021/acs.chemmater.8b01320 |
Appears in Collections: | Staff Publications Elements |
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