Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fcell.2020.00223
Title: | FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD). | Authors: | Tan, Yuanyang Qiao, Yongkang Chen, Zhuanggui Liu, Jing Guo, Yanrong Tran, Thai Tan, Kai Sen Wang, De-Yun Yan, Yan |
Keywords: | airway structural cells asthma chronic obstructive pulmonary disease fibroblast growth factor 2 immunomodulation therapeutics |
Issue Date: | 2020 | Publisher: | Frontiers Media SA | Citation: | Tan, Yuanyang, Qiao, Yongkang, Chen, Zhuanggui, Liu, Jing, Guo, Yanrong, Tran, Thai, Tan, Kai Sen, Wang, De-Yun, Yan, Yan (2020). FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD).. Front Cell Dev Biol 8 : 223-. ScholarBank@NUS Repository. https://doi.org/10.3389/fcell.2020.00223 | Abstract: | The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF family. It plays a role in airway remodeling associated with chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease (COPD). Recently, research interest has been raised in the immunomodulatory function of FGF2 in asthma and COPD, through its involvement in not only the regulation of inflammatory cells but also its participation as a mediator between immune cells and airway structural cells. Herein, this review provides the current knowledge on the biology of FGF2, its expression pattern in asthma and COPD patients, and its role as an immunomodulatory factor. The potential that FGF2 is involved in regulating inflammation indicates that FGF2 could be a therapeutic target for chronic inflammatory diseases. | Source Title: | Front Cell Dev Biol | URI: | https://scholarbank.nus.edu.sg/handle/10635/167246 | ISSN: | 2296-634X,2296-634X | DOI: | 10.3389/fcell.2020.00223 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD).pdf | Published version | 1.44 MB | Adobe PDF | OPEN | Published | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.