Please use this identifier to cite or link to this item: https://doi.org/10.3389/fcell.2020.00223
Title: FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD).
Authors: Tan, Yuanyang
Qiao, Yongkang 
Chen, Zhuanggui 
Liu, Jing 
Guo, Yanrong
Tran, Thai 
Tan, Kai Sen 
Wang, De-Yun 
Yan, Yan 
Keywords: airway structural cells
asthma
chronic obstructive pulmonary disease
fibroblast growth factor 2
immunomodulation therapeutics
Issue Date: 2020
Publisher: Frontiers Media SA
Citation: Tan, Yuanyang, Qiao, Yongkang, Chen, Zhuanggui, Liu, Jing, Guo, Yanrong, Tran, Thai, Tan, Kai Sen, Wang, De-Yun, Yan, Yan (2020). FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD).. Front Cell Dev Biol 8 : 223-. ScholarBank@NUS Repository. https://doi.org/10.3389/fcell.2020.00223
Abstract: The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF family. It plays a role in airway remodeling associated with chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease (COPD). Recently, research interest has been raised in the immunomodulatory function of FGF2 in asthma and COPD, through its involvement in not only the regulation of inflammatory cells but also its participation as a mediator between immune cells and airway structural cells. Herein, this review provides the current knowledge on the biology of FGF2, its expression pattern in asthma and COPD patients, and its role as an immunomodulatory factor. The potential that FGF2 is involved in regulating inflammation indicates that FGF2 could be a therapeutic target for chronic inflammatory diseases.
Source Title: Front Cell Dev Biol
URI: https://scholarbank.nus.edu.sg/handle/10635/167246
ISSN: 2296-634X,2296-634X
DOI: 10.3389/fcell.2020.00223
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