Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0096934
Title: Detection of antibodies against Turkey astrovirus in
Authors: Meliopoulos V.A.
Kayali G.
Burnham A.
Oshansky C.M.
Thomas P.G.
Gray G.C. 
Beck M.A.
Schultz-Cherry S.
Keywords: capsid protein
capsid protein
virus antibody
adult
antibody blood level
antibody detection
antibody production
antibody titer
antigen binding
article
Astrovirus
astrovirus infection
blood sampling
child
cohort analysis
controlled study
enzyme linked immunosorbent assay
flu like syndrome
human
immunoreactivity
major clinical study
nonhuman
occupational exposure
occupational hazard
population exposure
population research
poultry
seroprevalence
slaughterhouse
turkey astrovirus type 2
turkey astrovirus type 2 infection
United States
virus typing
agriculture
amino acid sequence
animal
animal husbandry
Astroviridae Infections
Astrovirus
blood
epidemiology
heterozygote
immunology
molecular genetics
turkey (bird)
virology
Abattoirs
Agriculture
Amino Acid Sequence
Animal Husbandry
Animals
Antibodies, Viral
Astroviridae Infections
Avastrovirus
Capsid Proteins
Carrier State
Humans
Midwestern United States
Molecular Sequence Data
Turkeys
Issue Date: 2014
Publisher: Public Library of Science
Citation: Meliopoulos V.A., Kayali G., Burnham A., Oshansky C.M., Thomas P.G., Gray G.C., Beck M.A., Schultz-Cherry S. (2014). Detection of antibodies against Turkey astrovirus in. PLoS ONE 9 (5) : e96934. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0096934
Abstract: Astroviruses are a leading cause of gastroenteritis in mammals and birds worldwide. Although historically thought to be species-specific, increasing evidence suggests that astroviruses may cross species barriers. In this report, we used enzyme-linked immunosorbent assays to screen sera from three distinct human cohorts involved in influenza studies in Memphis, TN or Chapel Hill, NC, and Midwestern poultry abattoir workers for antibodies to turkey astrovirus type 2 (TAstV-2). Surprisingly, 26% of one cohort's population was TAstV-2 positive as compared to 0 and 8.9% in the other cohorts. This cohort was composed of people with exposure to turkeys in the Midwestern United States including abattoir workers, turkey growers, and non-occupationally exposed participants. The odds of testing positive for antibodies against turkey astrovirus among abattoir workers were approximately 3 times higher than the other groups. These studies suggest that people with contact to turkeys can develop serological responses to turkey astrovirus. Further work is needed to determine if these exposures result in virus replication and/or clinical disease. © 2014 Meliopoulos et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/165950
ISSN: 19326203
DOI: 10.1371/journal.pone.0096934
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