Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0177834
Title: Site-specific phosphorylation of casein kinase 1δ(CK1δ) regulates its activity towards the circadian regulator PER2
Authors: Eng G.W.L. 
Edison 
Virshup D.M. 
Keywords: casein kinase Idelta
cycline
dinaciclib
PER2 protein
proline
staurosporine
casein kinase Idelta
circadian rhythm signaling protein
PER2 protein, human
serine
threonine
animal cell
Article
cell cycle
circadian rhythm
controlled study
embryo
enzyme activity
enzyme regulation
extracellular space
intracellular signaling
luciferase assay
mouse
nonhuman
protein degradation
protein domain
protein phosphorylation
protein stability
signal transduction
binding site
chemistry
gene expression regulation
genetics
HEK293 cell line
human
metabolism
mutation
phosphorylation
Binding Sites
Casein Kinase Idelta
Cell Cycle
Gene Expression Regulation
HEK293 Cells
Humans
Mutation
Period Circadian Proteins
Phosphorylation
Protein Stability
Serine
Signal Transduction
Threonine
Issue Date: 2017
Publisher: Public Library of Science
Citation: Eng G.W.L., Edison, Virshup D.M. (2017). Site-specific phosphorylation of casein kinase 1δ(CK1δ) regulates its activity towards the circadian regulator PER2. PLoS ONE 12 (5) : e0177834. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0177834
Abstract: Circadian rhythms are intrinsic ?24 hour cycles that regulate diverse aspects of physiology, and in turn are regulated by interactions with the external environment. Casein kinase 1 delta (CK1?, CSNK1D) is a key regulator of the clock, phosphorylating both stabilizing and destabilizing sites on the PER2 protein, in a mechanism known as the phosphoswitch. CK1? can itself be regulated by phosphorylation on its regulatory domain, but the specific sites involved, and the role this plays in control of circadian rhythms as well as other CK1-dependent processes is not well understood. Using a sensitized PER2
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/165794
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0177834
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