Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pgen.0020039
Title: Control of daily transcript oscillations in Drosophila by light and the circadian clock
Authors: Wijnen H.
Naef F.
Boothroyd C.
Claridge-Chang A. 
Young M.W.
Keywords: phospholipase C
messenger RNA
article
circadian rhythm
controlled study
Cyanobacterium
darkness
Drosophila
evoked visual response
eye
fly
fungus
genetic transcription
light
nonhuman
oscillation
photoperiodicity
phototransduction
plant
recording
synaptic transmission
time
wild type
animal
biological model
cluster analysis
Drosophila
gene expression regulation
genetics
light
metabolism
mutation
oscillometry
physiology
Cyanobacteria
Fungi
Protista
Animals
Circadian Rhythm
Cluster Analysis
Drosophila
Gene Expression Regulation
Light
Models, Biological
Mutation
Oscillometry
Phospholipase C
Phototransduction
RNA, Messenger
Synaptic Transmission
Issue Date: 2006
Publisher: Public Library of Science
Citation: Wijnen H., Naef F., Boothroyd C., Claridge-Chang A., Young M.W. (2006). Control of daily transcript oscillations in Drosophila by light and the circadian clock. PLoS Genetics 2 (3) : 326-343. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.0020039
Abstract: The transcriptional circuits of circadian clocks control physiological and behavioral rhythms. Light may affect such overt rhythms in two ways: (1) by entraining the clock circuits and (2) via clock-independent molecular pathways. In this study we examine the relationship between autonomous transcript oscillations and light-driven transcript responses. Transcript profiles of wild-type and arrhythmic mutant Drosophila were recorded both in the presence of an environmental photocycle and in constant darkness. Systematic autonomous oscillations in the 12- to 48-h period range were detectable only in wild-type flies and occurred preferentially at the circadian period length. However, an extensive program of light-driven expression was confirmed in arrhythmic mutant flies. Many light-responsive transcripts are preferentially expressed in the compound eyes and the phospholipase C component of phototransduction, NORPA (no receptor potential), is required for their light-dependent regulation. Although there is evidence for the existence of multiple molecular clock circuits in cyanobacteria, protists, plants, and fungi, Drosophila appears to possess only one such system. The sustained photic expression responses identified here are partially coupled to the circadian clock and may reflect a mechanism for flies to modulate functions such as visual sensitivity and synaptic transmission in response to seasonal changes in photoperiod. Copyright: © 2006 Wijnen et al.
Source Title: PLoS Genetics
URI: https://scholarbank.nus.edu.sg/handle/10635/165616
ISSN: 15537390
DOI: 10.1371/journal.pgen.0020039
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