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Title: Hypoxia regulates microRNA expression in the human carotid body
Authors: Mkrtchian S.
Lee K.L. 
Kåhlin J.
Ebberyd A.
Poellinger L. 
Fagerlund M.J.
Eriksson L.I.
Keywords: Carotid body
Issue Date: 2017
Publisher: Academic Press Inc.
Citation: Mkrtchian S., Lee K.L., Kåhlin J., Ebberyd A., Poellinger L., Fagerlund M.J., Eriksson L.I. (2017). Hypoxia regulates microRNA expression in the human carotid body. Experimental Cell Research 352 (2) : 412-419. ScholarBank@NUS Repository.
Abstract: The carotid body (CB) is the key sensing organ for physiological oxygen levels in the body. Under conditions of low oxygen (hypoxia), the CB plays crucial roles in signaling to the cardiorespiratory center in the medulla oblongata for the restoration of oxygen homeostasis. How hypoxia regulates gene expression in the human CB remains poorly understood. While limited information on transcriptional regulation in animal CBs is available, the identity and impact of important post-transcriptional regulators such as non-coding RNAs, and in particular miRNAs are not known. Here we show using ex vivo experiments that indeed a number of miRNAs are differentially regulated in surgically removed human CB slices when acute hypoxic conditions were applied. Analysis of the hypoxia-regulated miRNAs shows that they target biological pathways with upregulation of functions related to cell proliferation and immune response and downregulation of cell differentiation and cell death functions. Comparative analysis of the human CB miRNAome with the global miRNA expression patterns of a large number of different human tissues showed that the CB miRNAome had a unique profile which reflects its highly specialized functional status. Nevertheless, the human CB miRNAome is most closely related to the miRNA expression pattern of brain tissues indicating that they may have the most similar developmental origins. ? 2017 Elsevier Inc.
Source Title: Experimental Cell Research
ISSN: 144827
DOI: 10.1016/j.yexcr.2017.02.027
Appears in Collections:Staff Publications

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