Please use this identifier to cite or link to this item:
https://doi.org/10.1177/1756286418771815
Title: | Epigenetic regulation of inflammation in stroke | Authors: | Yong-Quan, Gavin Lim, Yun-An Sobey, Christopher G Dheen, Thameem Fann, David Yang-Wei Arumugam, Thiruma V |
Keywords: | cytokines epigenetics inflammasome ischaemic stroke neuroinflammation |
Issue Date: | 26-Apr-2018 | Publisher: | SAGE PUBLICATIONS LTD | Citation: | Yong-Quan, Gavin, Lim, Yun-An, Sobey, Christopher G, Dheen, Thameem, Fann, David Yang-Wei, Arumugam, Thiruma V (2018-04-26). Epigenetic regulation of inflammation in stroke. THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS 11 (0). ScholarBank@NUS Repository. https://doi.org/10.1177/1756286418771815 | Abstract: | Despite extensive research, treatments for clinical stroke are still limited only to the administration of tissue plasminogen activator and the recent introduction of mechanical thrombectomy, which can be used in only a limited proportion of patients due to time constraints. A plethora of inflammatory events occur during stroke, arising in part due to the body�s immune response to brain injury. Neuroinflammation contributes significantly to neuronal cell death and the development of functional impairment and death in stroke patients. Therefore, elucidating the molecular and cellular mechanisms underlying inflammatory damage following stroke injury will be essential for the development of useful therapies. Research findings increasingly point to the likelihood that epigenetic mechanisms play a role in the pathophysiology of stroke. Epigenetics involves the differential regulation of gene expression, including those involved in brain inflammation and remodelling after stroke. Hence, it is conceivable that epigenetic mechanisms may contribute to differential interindividual vulnerability and injury responses to cerebral ischaemia. In this review, we summarize recent findings on the emerging role of epigenetics in the regulation of neuroinflammation in stroke. We also discuss potential epigenetic targets that may be assessed for the development of stroke therapies. � The Author(s), 2018. | Source Title: | THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS | URI: | https://scholarbank.nus.edu.sg/handle/10635/163879 | ISSN: | 17562856 17562864 |
DOI: | 10.1177/1756286418771815 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
2018_Yong-Quan et al_Ther Adv Neurol Disord.pdf | 372.71 kB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.