Please use this identifier to cite or link to this item: https://doi.org/10.1080/1028415X.2019.1643624
Title: Associations of maternal zinc and magnesium with offspring learning abilities and cognitive development at 4 years in GUSTO
Authors: Lai JS
Cai S 
Feng L 
Shek LP 
Yap F 
Tan KH 
Chong YS 
Godfrey KM
Meaney MJ 
Rifkin-Graboi A
Broekman BFP 
Chong MFF 
Keywords: Zinc
Magnesium
Pregnancy
Cognition
School readiness
Memory
Numeracy
Language
Preschool
Child
Issue Date: 22-Jul-2019
Publisher: Maney Publishing
Citation: Lai JS, Cai S, Feng L, Shek LP, Yap F, Tan KH, Chong YS, Godfrey KM, Meaney MJ, Rifkin-Graboi A, Broekman BFP, Chong MFF (2019-07-22). Associations of maternal zinc and magnesium with offspring learning abilities and cognitive development at 4 years in GUSTO. Nutritional Neuroscience. ScholarBank@NUS Repository. https://doi.org/10.1080/1028415X.2019.1643624
Abstract: Objectives: Minerals deficiencies during pregnancy have been shown to be associated with poorer cognitive outcomes in offspring. This study aimed to investigate associations of maternal plasma zinc and magnesium concentrations with cognitive development in 4-year old children from the Growing Up in Singapore Towards healthy Outcome cohort. Methods: Maternal plasma zinc and magnesium concentrations were measured at 26-28 weeks' gestation. The Lollipop test of school readiness, tests of working memory, number knowledge, receptive vocabulary, and phonological awareness were performed in children at 4 years. Associations were examined in 715 mother-offspring pairs using linear regressions adjusted for key confounders. Results: Maternal plasma zinc and magnesium concentrations were 812 ± 144 µg/L and 19.9 ± 1.8 mg/L (mean±SD); 19% and 71% of mothers were zinc deficient and magnesium insufficient, respectively. After adjustment for multiple testing, higher maternal zinc concentrations (per SD increment) were associated with 0.35 higher scores in Lollipop subtest 2 of picture description and spatial identification (95% CI: 0.13, 0.58); higher maternal magnesium concentrations (per SD increment) were associated with 0.65 higher scores in Lollipop subtest 4 of letters and writing identification (95% CI: 0.23, 1.07). Discussion: No significant associations were observed for other tests, suggesting little long term influences of maternal zinc and magnesium on child's cognitive development.
Source Title: Nutritional Neuroscience
URI: https://scholarbank.nus.edu.sg/handle/10635/162059
ISSN: 1028415X
14768305
DOI: 10.1080/1028415X.2019.1643624
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
with Lai 2019. Maternal zinc magnesium with offspring cognition_Nut. Neuro..pdf1.47 MBAdobe PDF

CLOSED

Published

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.