Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pgen.1007079
Title: Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study
Authors: Davis J.P.
Huyghe J.R.
Locke A.E.
Jackson A.U.
Sim X. 
Stringham H.M.
Teslovich T.M.
Welch R.P.
Fuchsberger C.
Narisu N.
Chines P.S.
Kangas A.J.
Soininen P.
Ala-Korpela M.
Kuusisto J.
Laakso M.
Boehnke M.
Mohlke K.L.
Keywords: high density lipoprotein cholesterol
low density lipoprotein cholesterol
triacylglycerol
high density lipoprotein cholesterol
lipid
lipoprotein
triacylglycerol
ADAMTS3 gene
adult
Article
controlled study
Finn (citizen)
gene
gene frequency
gene locus
gene sequence
genetic variability
genome-wide association study
genotype
HIF3A gene
human
informed consent
LCAT gene
limit of quantitation
LIPC gene
LIPG gene
male
PLTP gene
single nucleotide polymorphism
smoking
Caucasian
exome
Finland
gene frequency
genetics
lipid metabolism
middle aged
principal component analysis
procedures
Cholesterol, HDL
European Continental Ancestry Group
Exome
Finland
Gene Frequency
Genome-Wide Association Study
Genotype
Humans
Lipid Metabolism
Lipids
Lipoproteins
Male
Middle Aged
Polymorphism, Single Nucleotide
Principal Component Analysis
Triglycerides
Issue Date: 2017
Citation: Davis J.P., Huyghe J.R., Locke A.E., Jackson A.U., Sim X., Stringham H.M., Teslovich T.M., Welch R.P., Fuchsberger C., Narisu N., Chines P.S., Kangas A.J., Soininen P., Ala-Korpela M., Kuusisto J., Laakso M., Boehnke M., Mohlke K.L. (2017). Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study. PLoS Genetics 13 (10) : e1007079. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1007079
Rights: CC0 1.0 Universal
Abstract: Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005<minor allele frequency [MAF]<0.05) or rare (MAF<0.005) variant, including Arg123His in LCAT. Gene-based associations (P<10?10) support a role for coding variants in LIPC and LIPG with lipoprotein subclass traits. 30 established lipid-associated loci had a stronger association for a subclass trait than any conventional trait. These novel association signals provide further insight into the molecular basis of dyslipidemia and the etiology of metabolic disorders. ? 2017 Public Library of Science. All Rights Reserved.
Source Title: PLoS Genetics
URI: https://scholarbank.nus.edu.sg/handle/10635/161889
ISSN: 15537390
DOI: 10.1371/journal.pgen.1007079
Rights: CC0 1.0 Universal
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