Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pgen.1007079
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dc.title | Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study | |
dc.contributor.author | Davis J.P. | |
dc.contributor.author | Huyghe J.R. | |
dc.contributor.author | Locke A.E. | |
dc.contributor.author | Jackson A.U. | |
dc.contributor.author | Sim X. | |
dc.contributor.author | Stringham H.M. | |
dc.contributor.author | Teslovich T.M. | |
dc.contributor.author | Welch R.P. | |
dc.contributor.author | Fuchsberger C. | |
dc.contributor.author | Narisu N. | |
dc.contributor.author | Chines P.S. | |
dc.contributor.author | Kangas A.J. | |
dc.contributor.author | Soininen P. | |
dc.contributor.author | Ala-Korpela M. | |
dc.contributor.author | Kuusisto J. | |
dc.contributor.author | Laakso M. | |
dc.contributor.author | Boehnke M. | |
dc.contributor.author | Mohlke K.L. | |
dc.date.accessioned | 2019-11-08T06:43:28Z | |
dc.date.available | 2019-11-08T06:43:28Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Davis J.P., Huyghe J.R., Locke A.E., Jackson A.U., Sim X., Stringham H.M., Teslovich T.M., Welch R.P., Fuchsberger C., Narisu N., Chines P.S., Kangas A.J., Soininen P., Ala-Korpela M., Kuusisto J., Laakso M., Boehnke M., Mohlke K.L. (2017). Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study. PLoS Genetics 13 (10) : e1007079. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1007079 | |
dc.identifier.issn | 15537390 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/161889 | |
dc.description.abstract | Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005<minor allele frequency [MAF]<0.05) or rare (MAF<0.005) variant, including Arg123His in LCAT. Gene-based associations (P<10?10) support a role for coding variants in LIPC and LIPG with lipoprotein subclass traits. 30 established lipid-associated loci had a stronger association for a subclass trait than any conventional trait. These novel association signals provide further insight into the molecular basis of dyslipidemia and the etiology of metabolic disorders. ? 2017 Public Library of Science. All Rights Reserved. | |
dc.rights | CC0 1.0 Universal | |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | |
dc.source | Unpaywall 20191101 | |
dc.subject | high density lipoprotein cholesterol | |
dc.subject | low density lipoprotein cholesterol | |
dc.subject | triacylglycerol | |
dc.subject | high density lipoprotein cholesterol | |
dc.subject | lipid | |
dc.subject | lipoprotein | |
dc.subject | triacylglycerol | |
dc.subject | ADAMTS3 gene | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | controlled study | |
dc.subject | Finn (citizen) | |
dc.subject | gene | |
dc.subject | gene frequency | |
dc.subject | gene locus | |
dc.subject | gene sequence | |
dc.subject | genetic variability | |
dc.subject | genome-wide association study | |
dc.subject | genotype | |
dc.subject | HIF3A gene | |
dc.subject | human | |
dc.subject | informed consent | |
dc.subject | LCAT gene | |
dc.subject | limit of quantitation | |
dc.subject | LIPC gene | |
dc.subject | LIPG gene | |
dc.subject | male | |
dc.subject | PLTP gene | |
dc.subject | single nucleotide polymorphism | |
dc.subject | smoking | |
dc.subject | Caucasian | |
dc.subject | exome | |
dc.subject | Finland | |
dc.subject | gene frequency | |
dc.subject | genetics | |
dc.subject | lipid metabolism | |
dc.subject | middle aged | |
dc.subject | principal component analysis | |
dc.subject | procedures | |
dc.subject | Cholesterol, HDL | |
dc.subject | European Continental Ancestry Group | |
dc.subject | Exome | |
dc.subject | Finland | |
dc.subject | Gene Frequency | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genotype | |
dc.subject | Humans | |
dc.subject | Lipid Metabolism | |
dc.subject | Lipids | |
dc.subject | Lipoproteins | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Principal Component Analysis | |
dc.subject | Triglycerides | |
dc.type | Article | |
dc.contributor.department | DEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH) | |
dc.contributor.department | LIFE SCIENCES INSTITUTE | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1371/journal.pgen.1007079 | |
dc.description.sourcetitle | PLoS Genetics | |
dc.description.volume | 13 | |
dc.description.issue | 10 | |
dc.description.page | e1007079 | |
Appears in Collections: | Elements Staff Publications |
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