Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pgen.1007079
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dc.titleCommon, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study
dc.contributor.authorDavis J.P.
dc.contributor.authorHuyghe J.R.
dc.contributor.authorLocke A.E.
dc.contributor.authorJackson A.U.
dc.contributor.authorSim X.
dc.contributor.authorStringham H.M.
dc.contributor.authorTeslovich T.M.
dc.contributor.authorWelch R.P.
dc.contributor.authorFuchsberger C.
dc.contributor.authorNarisu N.
dc.contributor.authorChines P.S.
dc.contributor.authorKangas A.J.
dc.contributor.authorSoininen P.
dc.contributor.authorAla-Korpela M.
dc.contributor.authorKuusisto J.
dc.contributor.authorLaakso M.
dc.contributor.authorBoehnke M.
dc.contributor.authorMohlke K.L.
dc.date.accessioned2019-11-08T06:43:28Z
dc.date.available2019-11-08T06:43:28Z
dc.date.issued2017
dc.identifier.citationDavis J.P., Huyghe J.R., Locke A.E., Jackson A.U., Sim X., Stringham H.M., Teslovich T.M., Welch R.P., Fuchsberger C., Narisu N., Chines P.S., Kangas A.J., Soininen P., Ala-Korpela M., Kuusisto J., Laakso M., Boehnke M., Mohlke K.L. (2017). Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study. PLoS Genetics 13 (10) : e1007079. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1007079
dc.identifier.issn15537390
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161889
dc.description.abstractLipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005<minor allele frequency [MAF]<0.05) or rare (MAF<0.005) variant, including Arg123His in LCAT. Gene-based associations (P<10?10) support a role for coding variants in LIPC and LIPG with lipoprotein subclass traits. 30 established lipid-associated loci had a stronger association for a subclass trait than any conventional trait. These novel association signals provide further insight into the molecular basis of dyslipidemia and the etiology of metabolic disorders. ? 2017 Public Library of Science. All Rights Reserved.
dc.rightsCC0 1.0 Universal
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.sourceUnpaywall 20191101
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlow density lipoprotein cholesterol
dc.subjecttriacylglycerol
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlipid
dc.subjectlipoprotein
dc.subjecttriacylglycerol
dc.subjectADAMTS3 gene
dc.subjectadult
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectFinn (citizen)
dc.subjectgene
dc.subjectgene frequency
dc.subjectgene locus
dc.subjectgene sequence
dc.subjectgenetic variability
dc.subjectgenome-wide association study
dc.subjectgenotype
dc.subjectHIF3A gene
dc.subjecthuman
dc.subjectinformed consent
dc.subjectLCAT gene
dc.subjectlimit of quantitation
dc.subjectLIPC gene
dc.subjectLIPG gene
dc.subjectmale
dc.subjectPLTP gene
dc.subjectsingle nucleotide polymorphism
dc.subjectsmoking
dc.subjectCaucasian
dc.subjectexome
dc.subjectFinland
dc.subjectgene frequency
dc.subjectgenetics
dc.subjectlipid metabolism
dc.subjectmiddle aged
dc.subjectprincipal component analysis
dc.subjectprocedures
dc.subjectCholesterol, HDL
dc.subjectEuropean Continental Ancestry Group
dc.subjectExome
dc.subjectFinland
dc.subjectGene Frequency
dc.subjectGenome-Wide Association Study
dc.subjectGenotype
dc.subjectHumans
dc.subjectLipid Metabolism
dc.subjectLipids
dc.subjectLipoproteins
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPrincipal Component Analysis
dc.subjectTriglycerides
dc.typeArticle
dc.contributor.departmentDEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH)
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1371/journal.pgen.1007079
dc.description.sourcetitlePLoS Genetics
dc.description.volume13
dc.description.issue10
dc.description.pagee1007079
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