Please use this identifier to cite or link to this item: https://doi.org/10.1177/0267659119839284
Title: Carbon dioxide removal using low bicarbonate dialysis in rodents
Authors: Vu, Lien H 
Kellum, John A
Federspiel, William J
Cove, Matthew E
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Peripheral Vascular Disease
Cardiovascular System & Cardiology
extracorporeal carbon dioxide removal
hemodialysis
hypercapnia
EXTRACORPOREAL CO2 REMOVAL
VENTILATION
DEVICE
MODEL
Issue Date: 1-Oct-2019
Publisher: SAGE PUBLICATIONS LTD
Citation: Vu, Lien H, Kellum, John A, Federspiel, William J, Cove, Matthew E (2019-10-01). Carbon dioxide removal using low bicarbonate dialysis in rodents. PERFUSION-UK 34 (7) : 578-583. ScholarBank@NUS Repository. https://doi.org/10.1177/0267659119839284
Abstract: © The Author(s) 2019. Background: Extracorporeal carbon dioxide removal may be used to manage hypercapnia, but compared to dialysis, it’s not widely available. A recent in vitro study showed that dialysis with low bicarbonate dialysates removes CO2. Objective: To show that bicarbonate dialysis removes CO2 in an animal model to validate in-vitro findings and quantify the effect on arterial pH. Methods: Male Sprague-Dawley hypercapnic rats were dialyzed with either a conventional dialysate (PrismasolTM) or a bicarbonate-free dialysate (Bicarb0). The effect of dialysis on standard blood gases and electrolytes was measured. Results: Partial pressure of CO2 and bicarbonate concentration in blood decreased significantly after exposure to Bicarb0 compared to PrismasolTM (filter outflow values 12.8 vs 81.1 mmHg; p < 0.01 for CO2 and 3.5 vs 22.0 mmol/L; p < 0.01 for bicarbonate). Total CO2 content of blood was reduced by 459 mL/L during dialysis with Bicarb0 (filter inflow 546 ± 91 vs filter outflow 87 ± 52 mL/L; p < 0.01), but was not significantly reduced with PrismasolTM. Conclusions: Bicarbonate dialysis removes CO2 at rates comparable to existing low-flow ECCO2R.
Source Title: PERFUSION-UK
URI: https://scholarbank.nus.edu.sg/handle/10635/161785
ISSN: 0267-6591
1477-111X
DOI: 10.1177/0267659119839284
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